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Unveiling Gene Expression Dynamics during Early Embryogenesis in Cynoglossus semilaevis: A Transcriptomic Perspective

文献类型： 外文期刊

作者： Cheng, Xinyi 1 ; Jiang, Wei 3 ; Wang, Qian 4 ; Liu, Kaiqiang 4 ; Dai, Wei 2 ; Liu, Yuyan 4 ; Shao, Changwei 4 ; Li, Qiye 2 ;

作者机构： 1.South China Univ Technol, Sch Biol & Biol Engn, Guangzhou 510006, Peoples R China

2.BGI Res, Wuhan 430074, Peoples R China

3.BGI Res, Shenzhen 518083, Peoples R China

4.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, State Key Lab Mariculture Biobreeding & Sustainabl, Qingdao 266071, Peoples R China

5.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China

6.Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China

关键词： Cynoglossus semilaevis; Cynoglossidae; gametes; early embryonic development; transcriptomics

期刊名称：LIFE-BASEL （ 影响因子：3.2； 五年影响因子：3.2 ）

ISSN：

年卷期： 2024 年 14 卷 4 期

页码：

收录情况： SCI

摘要： Commencing with sperm-egg fusion, the early stages of metazoan development include the cleavage and formation of blastula and gastrula. These early embryonic events play a crucial role in ontogeny and are accompanied by a dramatic remodeling of the gene network, particularly encompassing the maternal-to-zygotic transition. Nonetheless, the gene expression dynamics governing early embryogenesis remain unclear in most metazoan lineages. We conducted transcriptomic profiling on two types of gametes (oocytes and sperms) and early embryos (ranging from the four-cell to the gastrula stage) of an economically valuable flatfish-the Chinese tongue sole Cynoglossus semilaevis (Pleuronectiformes: Cynoglossidae). Comparative transcriptome analysis revealed that large-scale zygotic genome activation (ZGA) occurs in the blastula stage, aligning with previous findings in zebrafish. Through the comparison of the most abundant transcripts identified in each sample and the functional analysis of co-expression modules, we unveiled distinct functional enrichments across different gametes/developmental stages: actin- and immune-related functions in sperms; mitosis, transcription inhibition, and mitochondrial function in oocytes and in pre-ZGA embryos (four- to 1000-cell stage); and organ development in post-ZGA embryos (blastula and gastrula). These results provide insights into the intricate transcriptional regulation of early embryonic development in Cynoglossidae fish and expand our knowledge of developmental constraints in vertebrates.

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