Partridge tea polyphenols alleviated STZ-induced diabetic nephropathy by regulating Keap1/Nrf2/ARE signaling pathway in C57BL/6 mice
文献类型： 外文期刊
作者： Zhao, Mantong 1 ; Meng, Keke 1 ; Zhao, Meihui 1 ; Shi, Haohao 1 ; Liu, Zhongyuan 1 ; Yun, Yonghuan 1 ; Zhang, Weimin 1 ; Duan, Zhouwei 2 ; Xia, Guanghua 1 ;
作者机构： 1.Hainan Univ, Coll Food Sci & Technol, Hainan Engn Res Ctr Aquat Resources Efficient Util, Engn Res Ctr Utilizat Trop Polysaccharide Resource, Haikou 570228, Peoples R China
2.Hainan Acad Agr Sci, Inst Proc & Design Agroprod, Haikou 570228, Peoples R China
关键词： PTP; Diabetic nephropathy; Oxidative stress; Keap1/Nrf2/ARE signal pathway
期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：5.6； 五年影响因子：5.3 ）
ISSN： 1756-4646
年卷期： 2024 年 115 卷
页码：
收录情况： SCI
摘要： The present work investigated the effect of Partridge tea polyphenols (PTP) on streptozotocin (STZ)-induced diabetic mice as well as the underlying mechanism with rosiglitazone as positive control. Administration with PTP (250 or 500 mg/kg) for 5 weeks, compared to the diabetic nephropathy control group (DC group), PTP significantly decreased the renal index, creatinine in serum and urine, urea nitrogen and proteinuria and alleviated histopathological injury of renal tissue. The levels of TNF-alpha, IL-1 beta and IL-6 were decreased and SOD, CAT activities were increased by PTP. PTP significantly reduced the FN and COL -IV levels. Moreover, PTP significantly inhibited the Keap1 mRNA level of Keap1 and the corresponding protein expression, while increased the mRNA levels of Nrf2, HO-1, NQO1 and the corresponding protein expression. Therefore, PTP could reverse renal injury, enhance renal functions, inhibit renal oxidative stress, and activate Keap1/Nrf2/ARE signaling pathway to alleviative diabetic nephropathy.
- 相关文献
作者其他论文 更多>>
-
Ultrasonic-Assisted Extraction and Gastrointestinal Digestion Characteristics of Polysaccharides Extracted from Mallotus oblongfolius
作者：Tan, Gansheng;Duan, Zhouwei;Xin, Tian;Yang, Ling;Liu, Feng;Xie, Hui;Tan, Gansheng;Xia, Guanghua;Xin, Tian;Duan, Zhouwei;Yang, Ling;Liu, Feng;Xie, Hui
关键词：Mallotus oblongfolius polysaccharides (MOPS); ultrasonic extraction; gastrointestinal digestion; antioxidant properties; hypoglycaemia
-
Fabrication and characterization of piperine pickering emulsion Stabilized by zein/partridge tea polyphenol nanoparticles
作者：Wu, Yuchun;Duan, Zhouwei;Li, Chengpeng;Yang, Ling;Liu, Feng;Xie, Hui;Wu, Yuchun;Li, Chengpeng;Li, Congfa;Duan, Zhouwei;Yang, Ling;Liu, Feng;Xie, Hui
关键词：Zein; Partridge tea polyphenols; Piperine; Pickering emulsion; Stability
-
Protective Effect of Polyphenols Purified from Mallotus oblongfolius on Ethanol-Induced Gastric Mucosal Injury by Regulating Nrf2 and MAPKs Pathways
作者：Yu, Shasha;Duan, Zhouwei;Wang, Shiping;Xie, Hui;Yu, Shasha;Xia, Guanghua;Duan, Zhouwei;Wang, Shiping;Guo, Lijun;Xie, Hui;Duan, Zhouwei;Li, Peng
关键词：Mallotus oblongifolius polyphenols (MOP); purification; gastric mucosal injury; oxidative stress; ethanol
-
Protective Effects of Piperine on Ethanol-Induced Gastric Mucosa Injury by Oxidative Stress Inhibition
作者：Duan, Zhouwei;Yu, Shasha;Wang, Shiping;Deng, Hao;Xie, Hui;Duan, Zhouwei;Yang, Hong;Duan, Zhouwei;Wang, Shiping;Deng, Hao;Guo, Lijun;Xie, Hui;Yu, Shasha
关键词：piperine; GES-1 cells; gastric mucosal; oxidation
-
Piperine Derived from Piper nigrum L. Inhibits LPS-Induced Inflammatory through the MAPK and NF-kappa B Signalling Pathways in RAW264.7 Cells
作者：Duan, Zhouwei;Yang, Hong;Duan, Zhouwei;Xie, Hui;Yu, Shasha;Wang, Shiping;Yu, Shasha
关键词：Piper nigrum L.; anti-inflammatory; piperine; MAPK; NF-kappa B
-
Effect of a high-collagen peptide diet on the gut microbiota and short-chain fatty acid metabolism
作者：Mei, Fengfeng;Chen, Muxue;Lu, Jinfeng;Zhao, Meihui;Shen, Xuanri;Xia, Guanghua;Mei, Fengfeng;Li, Laihao;Chen, Shengjun;Duan, Zhouwei;Zhao, Meihui;Shen, Xuanri;Xia, Guanghua;Zhao, Meihui;Shen, Xuanri;Xia, Guanghua;Mei, Fengfeng;Chen, Muxue;Lu, Jinfeng;Zhao, Meihui;Shen, Xuanri;Xia, Guanghua
关键词：Collagen peptide; Gut microbiota; SCFA metabolism; Valerate acid
-
Collagen Peptides Isolated from Salmo salar and Tilapia nilotica Skin Accelerate Wound Healing by Altering Cutaneous Microbiome Colonization via Upregulated NOD2 and BD14
作者：Chen, Muxue;Meng, Keke;Shen, Xuanri;Xia, Guanghua;Mei, Fengfeng;Liu, Jingjie;Wu, Jintao;Chen, Muxue;Meng, Keke;Shen, Xuanri;Xia, Guanghua;Zhao, Meihui;Shen, Xuanri;Xia, Guanghua;Duan, Zhouwei;Chen, Shenjun
关键词：fish skin collagen peptide; wound healing; skin microbiome colonization; angiogenesis; inflammatory reaction
