您好，欢迎访问海南省农业科学院 机构知识库！
海南省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Collagen Peptides Isolated from Salmo salar and Tilapia nilotica Skin Accelerate Wound Healing by Altering Cutaneous Microbiome Colonization via Upregulated NOD2 and BD14

文献类型： 外文期刊

作者： Mei, Fengfeng 2 ; Liu, Jingjie 2 ; Wu, Jintao 2 ; Duan, Zhouwei 4 ; Chen, Muxue 1 ; Meng, Keke 1 ; Chen, Shenjun 5 ; Shen 1 ;

作者机构： 1.Hainan Univ, Hainan Engn Res Ctr Aquat Resources Efficient Uti, Haikou 570228, Hainan, Peoples R China

2.Hainan Univ, Coll Food Sci & Technol, Haikou 570228, Hainan, Peoples R China

3.Dalian Polytech Univ, Collaborat Innovat Ctr Marine Food Deep Proc, Dalian 116000, Liaoning, Peoples R China

4.Hainan Acad Agr Sci, Inst Proc & Design Agroprod, Haikou 570228, Hainan, Peoples R China

5.Chinese Acad Fishery Sci, South China Sea Fisheries Res Inst, Guangzhou 510000, Guangdong, Peoples R China

关键词： fish skin collagen peptide; wound healing; skin microbiome colonization; angiogenesis; inflammatory reaction

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）

ISSN： 0021-8561

年卷期： 2020 年 68 卷 6 期

页码：

收录情况： SCI

摘要： Collagen peptides can promote wound healing and are closely related to microbiome colonization. We investigated the relationship among collagen peptides, wound healing, and wound microflora colonization by administering the murine wound model with Salmo salar skin collagen peptides (Ss-SCPs) and Tilapia nilotica skin collagen peptides (Tn-SCPs). We analyzed the vascular endothelial growth factor (VEGF), fibroblast growth factors (beta-FGF), pattern recognition receptor (NOD2), antimicrobial peptides (beta-defence14, BD14), proinflammatory (TNF-alpha, IL-6, and IL-8) and anti-inflammatory (IL-10) cytokines, macrophages, neutrophil infiltration levels, and microbial communities in the rat wound. The healing rates of the Ss-SCP- and Tn-SCP-treated groups were significantly accelerated, associated with decreased TNF-alpha, IL-6, and IL-8 and upregulated BD14, NOD2, IL-10, VEGF, and beta-FGF. Accelerated healing in the collagen peptide group shows that the wound microflora such as Leuconostoc, Enterococcus, and Bacillus have a positive effect on wound healing (P < 0.01). Other microbiome species such as Stenotrophomonas, Bradyrhizobium, Sphingomonas, and Phyllobacterium had a negative influence and decreased colonization (P < 0.01). Altogether, these studies show that collagen peptide could upregulate wound NOD2 and BD14, which were implicated in microflora colonization regulation in the wound tissue and promoted wound healing by controlling the inflammatory reaction and increasing wound angiogenesis and collagen deposition.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：海南省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台