The Extract of Piper nigrum Improves the Cognitive Impairment and Mood in Sleep-Deprived Mice Through the JAK1/STAT3 Signalling Pathway
文献类型： 外文期刊
作者： Guan, Dongyan 1 ; Hou, Zhiying 1 ; Fan, Bei 1 ; Bai, Yajuan 1 ; Wu, Honghong 1 ; Yu, Jiawei 1 ; Xie, Hui 3 ; Duan, Zhouwei 3 ; Wang, Fengzhong 1 ; Wang, Qiong 1 ;
作者机构： 1.Chinese Acad Agr Sci, Inst Food Sci & Technol, Beijing 100193, Peoples R China
2.Chinese Acad Agr Sci, Natl Nanfan Res Inst Sanya, Sanya 572024, Peoples R China
3.Hainan Acad Agr Sci, Inst Proc & Design Agroprod, Haikou 571100, Peoples R China
关键词： piper extract; network pharmacology; sleep deprivation; cognitive impairment
期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：4.9； 五年影响因子：5.7 ）
ISSN： 1661-6596
年卷期： 2025 年 26 卷 5 期
页码：
收录情况： SCI
摘要： Piper nigrum L. (PN), which contains various bioactive compounds, is a plant with homologous medicine and food. Sleep deprivation (SD) profoundly impacts cognitive function and emotional health. However, the mechanisms by which PN improves cognitive function and depressive mood induced by SD remain unclear. In our study, network pharmacology and molecular docking techniques were used to predict the potential mechanisms by which PN regulates SD. In this study, 220 compounds were identified in PN, and 10 core targets were screened through network pharmacology. Animal experiments showed that PN ameliorated depressive mood and cognitive deficits in sleep-deprived mice, upregulated the serum activities of superoxide dismutase (SOD), glutathione (GSH), and catalase (CAT), and downregulated malondialdehyde (MDA) levels. The ELISA assay showed that PN significantly decreased the tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 beta (IL-1 beta) levels. Histopathological staining of brain tissue demonstrated that PN mitigates SD-induced hippocampal damage, enables the hippocampus to produce more neurotransmitters, including 5-hydroxytryptamine (5-HT), gamma-aminobutyric acid (GABA), and dopamine (DA), and reduces glutamate (Glu) levels. RT-qPCR and WB analyses further indicated that PN could exert anti-SD effects by inhibiting the over-activation of the JAK1/STAT3 signalling pathway. In the PC12 cell model, PN could reduce inflammation and prevent apoptosis, exerting neuroprotective effects. In summary, PN has positive effects on alleviating depressive symptoms and cognitive dysfunction induced by SD.
- 相关文献
作者其他论文 更多>>
-
Sensomics-based characterization of perceptual interactions between key odorants and polyphenols in Wuzhishan black tea
作者：Du, Wenbin;Li, Dongliang;Yang, Ling;Liu, Feng;Duan, Zhouwei;Xie, Hui;Du, Wenbin;Bi, Yongzhao;Ma, Qianli;Fang, Zongzhuang;Li, Dongliang;Yang, Ling;Liu, Feng;Duan, Zhouwei;Xie, Hui;Fang, Zongzhuang
关键词：Black tea flavor; Tea polyphenol; Olfactory threshold; Sensomics approach
-
Exploring the potential protective mechanism of Gastrodia elata Blume in Parkinson's disease using LC-MS/MS-based striatal metabolomics
作者：Guan, Dongyan;Wang, Fengzhong;Wang, Qiong;Guan, Dongyan;Wang, Qiong;Guan, Dongyan;Wang, Qiong;Wang, Mengdi;Zhang, Mijia;Wang, Qiong;Liu, Xinmin;Lu, Guanghua
关键词：Gastrodia elata Blume; Parkinson's disease; Striatum metabolomics; MPTP-Induced mouse model
-
Partridge tea polyphenols alleviated STZ-induced diabetic nephropathy by regulating Keap1/Nrf2/ARE signaling pathway in C57BL/6 mice
作者：Zhao, Mantong;Meng, Keke;Zhao, Meihui;Shi, Haohao;Liu, Zhongyuan;Yun, Yonghuan;Zhang, Weimin;Xia, Guanghua;Duan, Zhouwei
关键词：PTP; Diabetic nephropathy; Oxidative stress; Keap1/Nrf2/ARE signal pathway
-
Structural Characterization and Antidepressant-like Effects of Polygonum sibiricum Polysaccharides on Regulating Microglial Polarization in Chronic Unpredictable Mild Stress-Induced Zebrafish
作者：Zhang, Yingyu;Wang, Danyang;Liu, Jiameng;Bai, Yajuan;Fan, Bei;Lu, Cong;Wang, Fengzhong;Bai, Yajuan;Fan, Bei;Lu, Cong;Wang, Fengzhong
关键词：depression; Polygonati Rhizoma polysaccharides; microglia polarization
-
A low-cost discrete Vis-NIR optical sensing method for the determination of pear internal blackheart
作者：Li, Long;Zhang, Yifan;Sun, Yufeng;Tong, Litao;Fan, Bei;Yang, Huihui;Li, Minmin;Wang, Yutang;Wang, Fengzhong;Li, Long;Zhang, Yifan;Yang, Huihui;Li, Minmin;Wang, Yutang;Li, Long;Bai, Yajuan;Wang, Fengzhong
关键词：Pear blackheart disease; Micro-optical sensor; Savitzky-Golay convolution smoothing (SG); k nearest neighbor (KNN)
-
Ultrasonic-Assisted Extraction and Gastrointestinal Digestion Characteristics of Polysaccharides Extracted from Mallotus oblongfolius
作者：Tan, Gansheng;Duan, Zhouwei;Xin, Tian;Yang, Ling;Liu, Feng;Xie, Hui;Tan, Gansheng;Xia, Guanghua;Xin, Tian;Duan, Zhouwei;Yang, Ling;Liu, Feng;Xie, Hui
关键词：Mallotus oblongfolius polysaccharides (MOPS); ultrasonic extraction; gastrointestinal digestion; antioxidant properties; hypoglycaemia
-
Fabrication and characterization of piperine pickering emulsion Stabilized by zein/partridge tea polyphenol nanoparticles
作者：Wu, Yuchun;Duan, Zhouwei;Li, Chengpeng;Yang, Ling;Liu, Feng;Xie, Hui;Wu, Yuchun;Li, Chengpeng;Li, Congfa;Duan, Zhouwei;Yang, Ling;Liu, Feng;Xie, Hui
关键词：Zein; Partridge tea polyphenols; Piperine; Pickering emulsion; Stability
