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Abnormal Phenylalanine Metabolism of Procapra przewalskii in Chronic Selenosis in Selenium-Enriched Habitats

文献类型： 外文期刊

作者： Ren, Hong 1 ; Zhou, Ping 2 ; Shen, Xiaoyun 2 ;

作者机构： 1.North Sichuan Med Coll, Dept Anesthesiol, Nanchong 637100, Peoples R China

2.Xinjiang Acad Agr & Reclamat Sci, State Key Lab Sheep Genet Improvement & Hlth Prod, Shihezi 832000, Peoples R China

3.Southwest Univ Sci & Technol, Sch Life Sci & Engn, Mianyang 621010, Peoples R China

4.World Bank Poverty Alleviat Project Off Guizhou, Guiyang 550004, Peoples R China

关键词： P. przewalskii; phenylalanine; chronic selenosis; proteomics; metabolomics; biochemical analysis

期刊名称：METABOLITES （ 影响因子：4.1； 五年影响因子：4.5 ）

ISSN：

年卷期： 2023 年 13 卷 9 期

页码：

收录情况： SCI

摘要： Selenium (Se)-enriched habitats have led to chronic selenosis, seriously affecting the health and survival of Procapra przewalskii (P. przewalskii). Our targets were to explore the molecular mechanisms of chronic selenosis and to look for a new way to protect endangered species. The mineral contents of soils, grass, blood, and muscle were analyzed. The biochemical indices, antioxidant capability, and immune function were also investigated. The analyses of proteomics and metabolomics were also carried out. The results showed that the Se contents in the muscle and blood of P. przewalskii, and the soil and grass in the Se-enriched habitats were significantly higher than those in healthy pastures. The P. przewalskii in the Se-enriched habitats showed symptoms of anemia, decreased antioxidant capability, and low immune function. A total of 44 differential proteins and 36 differential metabolites were screened by analyzing their proteomics and metabolomics. These differential proteins and metabolites were involved in glycolysis pathway, amino acid biosynthesis, carbon metabolism, phenylalanine metabolism, and energy metabolism. In particular, phenylalanine metabolism was the common pathway of proteomics and metabolomics, which was an important finding in studying the mechanism of chronic selenosis in animals. This study will help us to further understand the mechanism of chronic selenosis in P. przewalskii, and it provides a scientific basis for the protection of endangered species in Se-enriched habitats.

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