文献类型： 外文期刊

作者： Huang, Siting ¹ ; Fu, Wusheng ¹ ; Fang, Qinmei ³ ; Ni, Lei ² ; Zheng, Renjin ² ; Yong, Ling ⁴ ; Huang, Zheng ² ; Pang, Jie ⁵ ; Lin, Zhong ² ; Lin, Honglin ² ; Dai, Rongde ¹ ;

作者机构： 1.Fujian Med Univ, Sch Publ Hlth, Fuzhou 350122, Peoples R China

2.Fujian Ctr Dis Control & Prevent, Hlth Inspection & Testing Inst, 386 Chongan Rd, Fuzhou 350012, Fujian, Peoples R China

3.Fujian Acad Agr, Inst Biotechnol, 247 Wusi Rd, Fuzhou 350003, Fujian, Peoples R China

4.China Natl Ctr Food Safety Risk Assessment, Beijing 100022, Peoples R China

5.Fujian Agr & Forestry Univ, Sch Food Sci, Fuzhou 350002, Peoples R China

6.Fujian Univ Tradit Chinese Med, Sch Med, Fuzhou 350108, Peoples R China

关键词： Aquatic product; N -nitrosamine; N -nitrosodimethylamine; Dietary exposure; Risk assessment; Margin of exposure

期刊名称：FOOD CONTROL （ 影响因子：6.0； 五年影响因子：5.8 ）

ISSN： 0956-7135

年卷期： 2023 年 152 卷

页码：

收录情况： SCI

摘要： N-nitrosamines are a class of carcinogenic chemicals. Despite considerable efforts to reduce their occurrence in drinking water, drugs and animal-derived foods, there have been few reports on the dietary assessment of N- nitrosamines in dried aquatic products, and their potential dietary exposure risk has remained unclear. There-fore, six N-nitrosamines were investigated in dried aquatic products in this study. The target analytes were quantified by LC-MS/MS coupled with the steam distillation. Among six N-nitrosamines, N-nitrosodimethyl-amine (NDMA) was detected in 77.8% (154/198) of the samples with an average level of 5.84 mu g/kg and 28.8% of the tested samples exceeded the limit set in Chinese National Standard for Food Safety 2762-2017. Furthermore, N-nitrosodiethylamine (NDEA) was only detected in four samples and no other classes of N-ni-trosamines were detected. Expanding upon this discovery, we further evaluated the carcinogenic risk of NDMA exposure in dried aquatic products via the margin of exposure (MOE) approach. The average intake of NDMA from dried aquatic products ranged from 1.90 to 2.04 ng/kg. bw/day for the male adults and from 3.17 to 4.84 ng/kg. bw/day for the male adolescents. Based on the average exposure of NDMA, the MOE value indicated no potential carcinogenic risks for the adults. However, the MOE value for the adolescents was significantly lower than 10,000, indicating the potential carcinogenic risks. For the 95th percentile highly exposed population, their MOE values were also below 10,000, indicating an associated carcinogenic risk for all age groups. Therefore, there is an urgent need to decrease or even eliminate the contamination of NDMA in dried aquatic products.