文献类型： 外文期刊

作者： Chen, Jing-Ze ¹ ; Fu, Wu-Sheng ¹ ; Xu, Fei ³ ; Fang, Qin-Mei ⁴ ; Zheng, Kui-Cheng ² ; Lin, Zhong ² ; Lin, Yi-Ming ⁵ ; Zhang, Sophia ⁶ ;

作者机构： 1.Fujian Med Univ, Sch Publ Hlth, Fuzhou, Fujian, Peoples R China

2.Fujian Ctr Dis Control & Prevent, Dept Phys & Chem Anal, 386 Chongan Rd, Fuzhou 350012, Fujian, Peoples R China

3.Ningxia Hui Autonomous Reg Ctr Dis Control & Prev, Phys & Chem Dept, Yinchuan, Ningxia, Peoples R China

4.Fujian Acad Agr Sci, Inst Biotechnol, 247 Wusi Rd, Fuzhou 350003, Fujian, Peoples R China

5.Xianyou Cty Ctr Dis Control & Prevent, Putian, Fujian, Peoples R China

6.Washington Univ, St Louis, MO 63110 USA

关键词： Muscarine; Muscimol; Ibotenic acid; Mushroom poisoning; Descriptive epidemiological investigation; Species identification

期刊名称：TOXICON （ 影响因子：3.035； 五年影响因子：2.874 ）

ISSN： 0041-0101

年卷期： 2022 年 212 卷

页码：

收录情况： SCI

摘要： Mushroom poisoning is a deeply concerning food safety problem that affects the public in China every year. Although there are statistics on the number of poisonings and incidents, there is a lack of data on the types of toxic mushrooms, clinical manifestations and toxins. A case of wild mushroom poisoning occurred in Xiamen. Descriptive epidemiological investigation, toxins detection, and morphological and phylogenetic identification were immediately performed. The patients exhibited typical neurotoxic symptoms after consuming wild mushrooms, including chills, vertigo, drowsiness, salivation and coma. The average incubation period was 30 min. Treatments that were adopted included fluid infusion, gastric lavage, catharsis, and liver protection treatment. All patients recovered within 10 days. The species was identified as Amanita pseudosychnopyramis, and its contents of muscarine, muscimol and ibotenic acid were 170.3 +/- 5.9 mg/kg, 835.4 +/- 43.1 mg/kg and 637.9 +/- 54.8 mg/kg in dry weight, respectively, as detected by ultrahigh-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). To our knowledge, this is the first report of Amanita pseudosychnopyramis poisoning worldwide.