Multi-omics profiling reveals the lipid metabolism during gonadal maturation in male Chinese mitten crab ( Eriocheir sinensis)
文献类型： 外文期刊
作者： Chen, Jianxiang 1 ; Xu, Pao 1 ; Xu, Gangchun 1 ; Xue, Miaomiao 1 ; Wang, Qingyong 1 ; He, Jiyan 1 ; He, Changchang 1 ; Kong, Changxin 1 ; Li, Xiaowei 1 ; Wang, Hang 1 ; Shen, Huaishun 1 ; Li, Hongxia 1 ; Song, Changyou 1 ;
作者机构： 1.Nanjing Agr Univ, Wuxi Fisheries Coll, Wuxi 214081, Peoples R China
2.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Key Lab Freshwater Fisheries & Germplasm Resources, Minist Agr & Rural Affairs, Wuxi 214081, Peoples R China
3.Suzhou Yangchenghu Modern Agr Dev Co Ltd, Suzhou 215138, Peoples R China
关键词： Male Eriocheir sinensis; Gonadal Maturation; Lipid Orchestration; Hepatopancreas
期刊名称：AQUACULTURE REPORTS （ 影响因子：3.7； 五年影响因子：4.0 ）
ISSN： 2352-5134
年卷期： 2024 年 39 卷
页码：
收录情况： SCI
摘要： Well-developed gonads determine the edible quality and progeny quality of the Chinese mitten crabs ( Eriocheir sinensis). However, there are fewer studies on gonad development in male crabs. To investigate the physiological changes during gonadal maturation in male crabs, we combined multi-omics to dissect metabolic modifications during gonadal development using immature male crabs (191.67 +/- 7.97 g) as a control and males that had undergone fattening as a treatment group. The result reveal PE(18:1(9Z)/0:0), L-a-Lysophosphatidylserine, PC (16:1(9Z)/18:2(9Z,12Z)), pregnanetriol and Alpinumisoflavone were selected as key markers during gonadal development. Additionally, lipid transport was considered the dominant metabolic difference. Specifically, mature gonads were characterized by higher phosphatidylcholines (PCs) and fewer triglycerides (TGs). Correlation analysis on differential lipids (DLMs) uncovered lipid regulation engaged in gonadal maturation in the male crab. A comparison of differential metabolites from the hepatopancreas in the same cohort demonstrated that hepatopancreas-mediated PCs were involved in the lipid orchestration of gonadal development. Based on transcriptome analysis, we identified that gonadal development enhanced meiosis ( spdya-a , aurka-a, espl1, cdk1 and smc1ad), stimulated the endocrine system ( atp1a1 , pfk, ppp2r3a, and cox7a), and decreased energy metabolism (AMPK signaling). Combined with correlation analysis between transcriptome and lipidome revealed lipids modulated physiological changes in the gonads. These findings contribute to the precise nutritional management of gonadal maturation in E. sinensis to improve quality of the gonads of male crab.
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