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Transcriptome signatures in common carp spleen in response to Aeromonas hydrophila infection

文献类型： 外文期刊

作者： Jiang, Yanliang 1 ; Feng, Shuaisheng 1 ; Zhang, Songhao 1 ; Liu, Hong 5 ; Feng, Jianxin 6 ; Mu, Xidong 7 ; Sun, Xiaowe 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Key Lab Aquat Genom, Ctr Appl Aquat Genom, Beijing 100141, Peoples R China

2.Chinese Acad Fishery Sci, Beijing Key Lab Fishery Biotechnol, Ctr Appl Aquat Genom, Beijing 100141, Peoples R China

3.Shanghai Ocean Univ, Coll Life Sci, Shanghai 201306, Peoples R China

4.Xiamen Univ, Fujian Collaborat Innovat Ctr Exploitat & Utiliza, Xiamen 361102, Peoples R China

5.Huazhong Agr Univ, Coll Fisheries, Key Lab Freshwater Anim Breeding, Minist Agr, Wuhan 430070, Peoples R China

6.Henan Acad Fishery Sci, Zhengzhou 450044, Peoples R China

7.Chinese Acad Fishery Sci, Minist Agr, Pearl River Fisheries Res Inst, Lab Trop & Subtrop Fishery Resource Applicat & Cu, Guangzhou 510380, Guangdong, Peoples R China

关键词： Transcriptome; Common carp; Aeromonas hydrophila; Bacterial infection

期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：4.581； 五年影响因子：4.851 ）

ISSN： 1050-4648

年卷期： 2016 年 57 卷

页码：

收录情况： SCI

摘要： The common carp is an important aquaculture species that is worldwide distributed. Nowadays, intensive rearing in aquaculture increases the susceptibility of fish to various pathogens such as Aeromonas hydrophila, which has caused severe damage to carp production. However, systematic analysis on the host response of common carp against A. hydrophila is less studied. In order to better understand the common carp immune response process against bacteria at the global gene expression level, we examined transcriptional profiles of the common carp spleen at three timepoints following experimental infection with A. hydrophila. A total of 545 million 125-bp paired end reads were generated, and all trimmed clean reads were mapped onto the common carp whole genome sequence. Comparison of the transcriptomes between the treatment and control group fish revealed 2900 unigenes with significantly differential expression, including 732, 936, 928 genes up-regulated, and 248, 475, 700 genes down regulated at 4 h, 12 h, 24 h post infection respectively. The captured significantly differentially expressed genes are mainly involved in the pathways including junction/adhesion, pathogen recognition, cell surface receptor signaling, and immune system process/defense response. Our study will provide fundamental information on molecular mechanism underlying the immune response of teleost against bacterial infection and might suggest strategies for selection of resistant strains of common carp in aquaculture. (C) 2016 Elsevier Ltd. All rights reserved.

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