Alterations in cellular RNA decapping dynamics affect tomato spotted wilt virus cap snatching and infection in Arabidopsis
文献类型： 外文期刊
作者： Ma, Xiaofang 1 ; Zhou, Yijun 1 ; Moffett, Peter 2 ;
作者机构： 1.Jiangsu Acad Agr Sci, Jiangsu Tech Serv Ctr Diag & Detect Plant Virus D, Inst Plant Protect, 50 Zhongling St, Nanjing 210014, Jiangsu, Peoples R China
2.Univ Sherbrooke, Ctr SEVE, Dept Biol, 2500 Blvd Univ, Sherbrooke, PQ J1K 2R1, Canada
关键词： bunyavirus; cap snatching; DCP2; decapping; TSWV; UPF1; XRN4
期刊名称：NEW PHYTOLOGIST （ 影响因子：10.151； 五年影响因子：10.475 ）
ISSN： 0028-646X
年卷期： 2019 年 224 卷 2 期
页码：
收录情况： SCI
摘要： RNA processing and decay pathways have important impacts on RNA viruses, particularly animal-infecting bunyaviruses, which utilize a cap-snatching mechanism to translate their mRNAs. However, their effects on plant-infecting bunyaviruses have not been investigated. The roles of mRNA degradation and non-sense-mediated decay components, including DECAPPING 2 (DCP2), EXORIBONUCLEASE 4 (XRN4), ASYMMETRIC LEAVES2 (AS2) and UP-FRAMESHIFT 1 (UPF1) were investigated in infection of Arabidopsis thaliana by several RNA viruses, including the bunyavirus, tomato spotted wilt virus (TSWV). TSWV infection on mutants with decreased or increased RNA decapping ability resulted in increased and decreased susceptibility, respectively. By contrast, these mutations had the opposite, or no, effect on RNA viruses that use different mRNA capping strategies. Consistent with this, the RNA capping efficiency of TSWV mRNA was higher in a dcp2 mutant. Furthermore, the TSWV N protein partially colocalized with RNA processing body (PB) components and altering decapping activity by heat shock or coinfection with another virus resulted in corresponding changes in TSWV accumulation. The present results indicate that TSWV infection in plants depends on its ability to snatch caps from mRNAs destined for decapping in PBs and that genetic or environmental alteration of RNA processing dynamics can affect infection outcomes.
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