Downregulating NF-kappa B signaling pathway with triterpenoids for attenuating inflammation: in vitro and in vivo studies
文献类型： 外文期刊
作者： Chen, Min 1 ; Qin, Ying 1 ; Ma, Hang 1 ; Zheng, Xi 4 ; Zhou, Renping 4 ; Sun, Shili 5 ; Huang, Yiqi 1 ; Duan, Qing 1 ; Liu, 1 ;
作者机构： 1.Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Guangdong, Peoples R China
2.Int Healthcare Innovat Inst Jiangmen, Jiangmen 529040, Guangdong, Peoples R China
3.Univ Rhode Isl, Coll Pharm, Dept Biomed & Pharmaceut Sci, Bioact Bot Res Lab, Kingston, RI 02881 USA
4.Rutgers State Univ, Ernest Mario Sch Pharm, Dept Chem Biol, Susan Lehman Cullman Lab Canc Res, Piscataway, NJ 08854 USA
5.Guangdong Acad Agr Sci, Tea Res Inst, Guangdong Prov Key Lab Tea Plant Resources Innova, Dafeng Rd 6, Guangzhou 510640, Guangdong, Peoples R China
期刊名称：FOOD & FUNCTION （ 影响因子：5.396； 五年影响因子：5.534 ）
ISSN： 2042-6496
年卷期： 2019 年 10 卷 8 期
页码：
收录情况： SCI
摘要： Acanthopanax trifoliatus (L.) Merr., an edible medicinal plant from Southeast Asia, exerts a wide range of bioactivities, such as anti-inflammatory activity. However, the anti-inflammatory mechanisms of its action and active constituents remain unclear. Herein, the effects of two triterpenoids, namely impressic acid (IA) and acankoreanogenin A (AA), from A. trifoliatus in both in vitro and in vivo chronic inflammation models were investigated. The results indicated that AA and IA reduced lipopolysaccharide (LPS)-induced production of nitroxide significantly in murine macrophage RAW246.7 cells. In addition, AA and IA down-regulated the activation of NF-kappa B and decreased the release of inflammatory mediators (iNOS, COX-2, TNF-alpha, and IL-6) and tumorigenesis-associated factors (MMP-9 and VEGF) in RAW246.7 cells. Furthermore, in a tetradecanoylphorbolacetate (TPA)-treated mouse model, AA and IA could effectively attenuate mouse ear edema and pathological damage and reduced levels of cytokines including iNOS, COX-2, TNF-alpha, and IL-1 beta. Taken together, AA and IA, being of natural origin, are promising anti-inflammatory agents and may contribute to the overall anti-inflammatory effect of A. trifoliatus.
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