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Genetic and phylogenetic analyses of the first GIII.2 bovine norovirus in China

文献类型： 外文期刊

作者： Shi, Zhihai 1 ; Wang, Wenjia 3 ; Xu, Zhaoxue 1 ; Zhang, Xiaozhan 4 ; Lan, Yali 1 ;

作者机构： 1.Henan Acad Agr Sci, Inst Anim Husb & Vet Sci, Zhengzhou 450002, Henan, Peoples R China

2.Henan Key Lab Farm Anim Breeding & Nutr Regulat, Zhengzhou 450002, Henan, Peoples R China

3.Henan Univ Anim Husb & Econ, Coll Pharmaceut Engn, Zhengzhou 450046, Henan, Peoples R China

4.Henan Univ Anim Husb & Econ, Coll Vet Med, Zhengzhou 450046, Henan, Peoples R China

关键词： Bovine norovirus; Diarrhoea; Phylogenetic analyses; China

期刊名称：BMC VETERINARY RESEARCH （ 影响因子：2.741； 五年影响因子：2.955 ）

ISSN：

年卷期： 2019 年 15 卷 1 期

页码：

收录情况： SCI

摘要： Background Norovirus (NoV) is recognized as a highly contagious enteric pathogen of mammals, and bovine norovirus (BNoV) is associated with calf diarrhoea and has caused great economic losses in the cattle industry. Results Here, we describe a case of emerging calf diarrhoea on a cattle farm in Henan Province, Central China. BNoV was the only enteric pathogen detected in outbreaks according to tests for enteric viruses, bacteria and parasites. The complete genome of the newly identified strain CH-HNSC-2018 was successfully sequenced and found to be 7342 nucleotides in length. Sequence and phylogenetic analyses revealed that CH-HNSC-2018 belongs to GIII.2 BNoV. Further analysis of the major capsid protein demonstrated that it is separated by specific genetic distances from previous BNoV strains identified in China and has 4 new amino acid (aa) mutations, 134A, 327 T, 380 L and 423A, in the VP1 protein and 11 aa substitutions in the hypervariable P2 subdomain, suggesting that the BNoV strains circulating in China are diverse. Conclusions This is the first detection of GIII.2 BNoV in the VP1 region in China. This report should form a basis for further molecular studies on NoV and bovine enteric viruses in China.

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