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NPR1 Promotes Its Own and Target Gene Expression in Plant Defense by Recruiting CDK8

文献类型： 外文期刊

作者： Chen, Jian 1 ; Mohan, Rajinikanth 3 ; Zhang, Yuqiang 4 ; Li, Min 2 ; Chen, Huan 1 ; Palmer, Ian Arthur 2 ; Chang, Ming 1 ;

作者机构： 1.Minist Sci & Technol, Jiangsu Acad Agr Sci, State Key Lab Cultivat Base, Inst Plant Protect,Jiangsu Key Lab Food Qual & Sa, Nanjing 210014, Peoples R China

2.Univ South Carolina, Dept Biol Sci, Columbia, SC 29208 USA

3.Duke Univ, Dept Biol, Durham, NC 27708 USA

4.Nanjing Agr Univ, Dept Plant Pathol, Nanjing 210095, Jiangsu, Peoples R China

5.Henan Agr Univ, State Key Lab Wheat & Maize Crop Sci, Zhengzhou 450002, Henan, Peoples R China

6.Henan Agr Univ, Coll Agron, Zhengzhou 450002, Henan, Peoples R China

7.Purdue Univ, Dept Bot & Plant Pathol, W Lafayette, IN 47907 USA

期刊名称：PLANT PHYSIOLOGY （ 影响因子：8.34； 五年影响因子：8.972 ）

ISSN： 0032-0889

年卷期： 2019 年 181 卷 1 期

页码：

收录情况： SCI

摘要： NPR1 (NONEXPRESSER OF PR GENESI) functions as a master regulator of the plant hormone salicylic acid (SA) signaling and plays an essential role in plant immunity. In the nucleus, NPR1 interacts with transcription factors to induce the expression of PR (PATHOGENESIS-RELATED) genes and thereby promote defense responses. However, the underlying molecular mechanism of PR gene activation is poorly understood. Furthermore, despite the importance of NPR1 in plant immunity, the regulation of NPR1 expression has not been extensively studied. Here, we show that SA promotes the interaction of NPR1 with both CDK8 (CYCLIN-DEPENDENT KINASE8) and WRKY18 (WRKY DNA-BINDING PROTEIN18) in Arabidopsis (Arabidopsis thaliana). NPR1 recruits CDK8 and WRKY18 to the NPR1 promoter, facilitating its own expression. Intriguingly, CDK8 and its associated Mediator subunits positively regulate NPR1 and PRI expression and play a pivotal role in local and systemic immunity. Moreover, CDK8 interacts with WRKY6, WRKY18, and TGA transcription factors and brings RNA polymerase II to NPR1 and PRI promoters and coding regions to facilitate their expression. Our studies reveal a mechanism in which NPR1 recruits CDK8, WRKY18, and TGA transcription factors along with RNA polymerase II in the presence of SA and thereby facilitates its own and target gene expression for the establishment of plant immunity.

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