Syndapin constricts microvillar necks to form a united rhabdomere in Drosophila photoreceptors
文献类型： 外文期刊
作者： Ogi, Sakiko 1 ; Matsuda, Atsushi 2 ; Otsuka, Yuna 1 ; Liu, Ziguang 1 ; Satoh, Takunori 1 ; Satoh, Akiko K. 1 ;
作者机构： 1.Hiroshima Univ, Grad Sch Integral Sci Life, Program Life & Environm Sci, 1-7-1 Kagamiyama, Hiroshima 7398521, Japan
2.Adv ICT Res Inst, Natl Inst Informat & Commun Technol, Nishi Ku, 588-2 Iwaoka, Kobe, Hyogo 6512492, Japan
3.Heilongjiang Acad Agr Sci, Inst Anim Husb, Xuefu Rd 368, Harbin 150086, Heilongjiang, Peoples R China
关键词： Syndapin; Rhabdomeres; Microvilli; F-BAR; ERM
期刊名称：DEVELOPMENT （ 影响因子：6.868； 五年影响因子：7.522 ）
ISSN： 0950-1991
年卷期： 2019 年 146 卷 16 期
页码：
收录情况： SCI
摘要： Drosophila photoreceptors develop from polarized epithelial cells that have apical and basolateral membranes. During morphogenesis, the apical membranes subdivide into a united bundle of photosensory microvilli (rhabdomeres) and a surrounding supporting membrane (stalk). By EMS-induced mutagenesis screening, we found that the F-Bin/Amphiphysin/Rvs (F-BAR) protein syndapin is essential for apical membrane segregation. The analysis of the super-resolution microscopy, STORM and the electron microscopy suggest that syndapin localizes to the neck of the microvilli at the base of the rhabdomere. Syndapin and moesin are required to constrict the neck of the microvilli to organize the membrane architecture at the base of the rhabdomere, to exclude the stalk membrane. Simultaneous loss of syndapin along with the microvilli adhesion molecule chaoptin significantly enhanced the disruption of stalk-rhabdomere segregation. However, loss of the factors involving endocytosis do not interfere. These results indicated syndapin is most likely functioning through its membrane curvature properties, and not through endocytic processes for stalk-rhabdomere segregation. Elucidation of the mechanism of this unconventional domain formation will provide novel insights into the field of cell biology.
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