Drosophila jumu modulates apoptosis via a JNK-dependent pathway and is required for other processes in wing development
文献类型： 外文期刊
作者： Wang, Xiao Chun 1 ; Liu, Ziguang 2 ; Jin, Li Hua 1 ;
作者机构： 1.Northeast Forestry Univ, Dept Genet, Coll Life Sci, Harbin 150040, Heilongjiang, Peoples R China
2.Heilongjiang Acad Agr Sci, Harbin 150040, Heilongjiang, Peoples R China
关键词： Jumu; Apoptosis; JNK pathway; Wing development
期刊名称：APOPTOSIS （ 影响因子：4.677； 五年影响因子：4.857 ）
ISSN： 1360-8185
年卷期： 2019 年 24 卷 5-6 期
页码：
收录情况： SCI
摘要： Previous studies in several model organisms have revealed that members of the Forkhead (Fkh) transcription factor family have multiple functions. Drosophila Jumeau (Jumu), a member of this family, participates in cardiogenesis, hematopoiesis and immune system homeostasis. Here, we show that loss of jumu function positively regulates or triggers apoptosis via a JNK-dependent pathway in wing development. jumu mutants showed reduced wing size and increased apoptosis. Moreover, we observed a loss of the anterior cross vein (ACV) phenotype that was similar to that observed in wings in which JNK signaling has been ectopically activated. The JNK signaling markers puckered (puc) and p-JNK were also significantly increased in the wing discs of jumu mutants. In addition, apoptosis induced by the loss of jumu was rescued by knocking down JNK, indicating a role for JNK in reducing jumu-induced apoptosis. Jumu could also control wing margin development via the positive regulation of cut expression, and the observed wing margin defect did not result from a loss of jumu-induced apoptosis. Further, jumu deficiency in the pupal wing could induce multiple wing hairs via a Rho1-mediated planar cell polarity pathway, but abnormal Rho1 expression was not why jumu loss induced apoptosis via a JNK-dependent pathway in wing discs.
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