文献类型： 外文期刊
作者： Qin, Bo 1 ; Xue, Hongmei 3 ; Wang, Xiaoran 1 ; Kim, Hyonil 1 ; Jin, Li Hua 1 ;
作者机构： 1.Northeast Forestry Univ, Coll Life Sci, Harbin 150040, Peoples R China
2.Heilongjiang Acad Agr Sci, Inst Crop Breeding, Harbin, Peoples R China
3.Peking Univ Peoples Hosp, Qingdao, Peoples R China
4.Qingdao Univ, Women & Childrens Hosp, Qingdao, Peoples R China
5.Kim Il Sung Univ, Coll Life Sci, Pyongyang, South Korea
关键词：
Atg2;
期刊名称：FEBS JOURNAL （ 影响因子：4.2； 五年影响因子：5.6 ）
ISSN： 1742-464X
年卷期： 2025 年 292 卷 2 期
页码：
收录情况： SCI
摘要： The hematopoietic system of Drosophila is a well-established genetic model for studying hematopoiesis mechanisms, which are strictly regulated by multiple signaling pathways. Autophagy-related 2 (Atg2) protein is involved in autophagosome formation through its lipid transfer function; however, other functions in animal development, especially the role of Atg2 in maintaining hematopoietic homeostasis, are unclear. Here, we show that Atg2 knockdown in the cortical zone (CZ) induced the proliferation and differentiation of mature plasmatocytes and disrupted progenitor maintenance in the medullary zone (MZ). We also observed the differentiation of lamellocytes among circulating hemocytes and in the lymph gland, which is rarely observed in healthy larvae. The above results on hematopoiesis disorders are due to Atg2 regulating the Drosophila PDGF/VEGF receptor (PVR) and target of rapamycin (TOR) in the CZ of lymph gland. In conclusion, we identified Atg2 as a previously undescribed regulator of hematopoiesis. Understanding the mechanism of maintenance of hematopoietic homeostasis in Drosophila will help us better evaluate human blood disorder-related diseases.
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