Long non-coding RNA profiling in LPS-induced intestinal inflammation model: New insight into pathogenesis
文献类型： 外文期刊
作者： Guo, Ling 1 ; Li, Linna 1 ; Zhang, Yang 1 ; Fu, Shulin 1 ; Zhang, Jing 1 ; Wang, Xiuying 1 ; Zhu, Huiling 1 ; Qiao, Mu 3 ; W 1 ;
作者机构： 1.Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Hubei, Peoples R China
2.Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Wuhan, Hubei, Peoples R China
3.Hubei Acad Agr Sci, Key Lab Anim Embryo Engn & Mol Breeding Hubei Pro, Inst Anim Husb & Vet, Wuhan, Hubei, Peoples R China
关键词： Long non-coding RNA; lipopolysaccharide; intestinal inflammation; cam signalling pathway; mTOR signalling pathway
期刊名称：INNATE IMMUNITY （ 影响因子：2.68； 五年影响因子：2.868 ）
ISSN： 1753-4259
年卷期： 2019 年 25 卷 8 期
页码：
收录情况： SCI
摘要： LPS can induce an inflammatory immune response in the intestine, and long non-coding RNA (lncRNA) is involved in the process of inflammatory disease. However, the biological role of lncRNA in the intestinal inflammation of piglets remains unclear. In this study, the lncRNA expression profile of the ileal mucosa of piglets challenged by LPS was analysed using lncRNA sequencing. In total, 112 novel lncRNAs were predicted, of which 58 were up-regulated and 54 down-regulated following LPS challenge. Expression of 15 selected lncRNAs was validated by quantitative PCR. We further investigated the target genes of lncRNA that were enriched in the signalling pathways involved in the inflammatory immune response by utilising Gene Ontology and Kyoto Encyclopaedia of Genes and Genomes analysis, with cell adhesion molecules and mTOR signalling pathway identified. In addition, the co-expression networks between the differentially expressed lncRNAs and the target mRNAs were constructed, with seven core lncRNAs identified, which also demonstrated that the relationship between lncRNAs and the target genes was highly correlated. Our study offers important information about the lncRNAs of the mucosal immune system in piglets and provides new insights into the inflammatory mechanism of LPS challenge, which might serve as a novel target to control intestinal inflammation.
- 相关文献
作者其他论文 更多>>
-
Post-Translational Modifications in Mammalian Folliculogenesis and Ovarian Pathologies
作者：Chen, Dake;Feng, Yue;Wu, Junjing;Zhou, Jiawei;Li, Zipeng;Qiao, Mu;Chen, Tong;Xu, Zhong;Peng, Xianwen;Mei, Shuqi
关键词：post-translational modification; follicular development; polycystic ovary syndrome; premature ovarian insufficiency
-
SIRT7 deletion inhibits Glaesserella parasuis-mediated inflammatory responses in porcine alveolar macrophages
作者：Zheng, Hao;Wang, Baoxin;Dong, Xia;Shi, Liangyu;Zhang, Jing;Chen, Hongbo;Zhou, Ao;Zheng, Hao;Wang, Baoxin;Dong, Xia;Shi, Liangyu;Zhang, Jing;Chen, Hongbo;Zhou, Ao;Wu, Junjing
关键词：SIRT7;
Glaesserella parasuis ; inflammatory responses; CRISPR/Cas9; disease-resistant breeding -
Influence of the temperature during grain filling stage and nitrogen application rate on yield and quality of indica hybrid rice
作者：Lu, Bo;Xu, Congshan;Li, Ziyu;Tang, Xinao;Yang, Fei;Jiang, Yu;Li, Weiwei;Liu, Zhenghui;Ding, Yanfeng;Li, Ganghua;Xu, Deze;Zhu, Guofu;Zhang, Jing
关键词：Temperature; Nitrogen application; Grain yield; Grain quality; Indica hybrid rice
-
Nitrogen application increased yield sensitivity of indica hybrid rice to climate resource
作者：Lu, Bo;Li, Ziyu;Yang, Fei;Zhang, Jianwei;Li, Weiwei;Qian, Haoyu;Jiang, Yu;Liu, Zhenghui;Ding, Yanfeng;Li, Ganghua;Xu, Congshan;Tang, Xinao;Li, Ganghua;Ding, Chao;Xu, Deze;Zhu, Guofu;Zhang, Jing
关键词：Sowing date; Nitrogen application rate; Grain yield; Climate resource; Indica hybrid rice
-
Integration of ATAC-Seq and RNA-Seq Reveals VDR-SELENBP1 Axis Promotes Adipogenesis of Porcine Intramuscular Preadipocytes
作者：Zhou, Jiawei;Wu, Junjing;Yang, Tao;Zhang, Xinyu;Qiao, Mu;Xu, Zhong;Zhang, Yu;Feng, Yue;Chen, Tong;Li, Zipeng;Peng, Xianwen;Mei, Shuqi;Zhang, Xinyu
关键词：pig; intramuscular fat; accessible chromatin;
SELENBP1 ; adipogenic differentiation -
Transcriptomic and sugar metabolic analysis reveals molecular mechanisms of peach gummosis in response to Neofusicoccum parvum infection
作者：Zhang, Yang;Liu, Yong;Gan, Zhimeng;Du, Wei;Ai, Xiaoyan;Zhu, Wei;Wang, Huiliang;Wang, Furong;Gong, Linzhong;He, Huaping
关键词：peach; gummosis;
N. parvum ; transcriptome; sugar metabolome -
Natural variations of HvSRN1 modulate the spike rachis node number in barley
作者：Fan, Chaofeng;Xu, Dongdong;Wang, Chunchao;Chen, Zhaoyan;Dou, Tingyu;Guo, Aikui;Zhao, Meng;Pei, Honghong;Zhao, Mengwei;Zhang, Renxu;Wang, Ke;Zhang, Jing;Guo, Ganggang;Fan, Chaofeng;Xu, Dongdong;Ni, Zhongfu;Qin, Dandan
关键词：barley; fine-mapping; grain number; kernel weight
