A genome-wide association study of resistance to Pseudomonas plecoglossicida infection in the large yellow croaker (Larimichthys crocea)
文献类型： 外文期刊
作者： Wan, Liang 1 ; Wang, Weijia 2 ; Liu, Guijia 2 ; Dong, Linsong 2 ; Li, Wanbo 2 ; Han, Zhaofang 2 ; Ye, Kun 4 ; Wang, Zhiyo 1 ;
作者机构： 1.Hunan Agr Univ, Coll Anim Sci & Technol, Changsha, Hunan, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266235, Shandong, Peoples R China
3.Minist Agr, Key Lab Hlth Mariculture East China Sea, Beijing, Peoples R China
4.Jimei Univ, Fisheries Coll, Xiamen, Fujian, Peoples R China
5.Chinese Acad Fishery Sci, South China Sea Fisheries Res Inst, Beijing, Peoples R China
关键词： GWAS; Pseudomonas plecoglossicida; Large yellow croaker; Disease resistance
期刊名称：AQUACULTURE INTERNATIONAL （ 影响因子：2.235； 五年影响因子：2.616 ）
ISSN： 0967-6120
年卷期： 2019 年 27 卷 5 期
页码：
收录情况： SCI
摘要： Cultured large yellow croaker (Larimichthys crocea) is frequently infected by bacteria, thus developing small white granulomas in the spleen and kidneys with high mortality in a few days. We performed a genome-wide association study (GWAS) on the trait of resistance to Pseudomonas plecoglossicida infection in a large yellow croaker population in 222 extreme-phenotype samplings using the whole-genome resequencing technology. With the 254,110 detected SNPs for the trait, three candidate regions associated with disease resistance were found on chromosomes 3, 5 and 20. By combing our GWAS results with the biological functional analysis of immunity genes, we found that IL10, THBS1, IGSF21, IGR and IGH as well as IRF8, TRAIL, CC, TNF and LINGO1 are candidate genes of the disease resistance trait in the large yellow croaker. Moreover, after comparison with transcriptome sequencing data, we found that the candidate genes from GWAS were actually up-regulated or down-regulated. This is the first time that a GWAS combined with a transcriptome-wide study was performed on disease resistance to detect candidate loci and find potential functionally relevant genes in the large yellow croaker.
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