Combination of mulberry leaf and oat bran possessed greater hypoglycemic effect on diabetic mice than mulberry leaf or oat bran alone
文献类型： 外文期刊
作者： Hu, Teng-Gen 1 ; Wen, Peng 2 ; Liu, Jun 1 ; Long, Xiao-Shan 1 ; Liao, Sen-Tai 1 ; Wu, Hong 2 ; Zou, Yu-Xiao 1 ;
作者机构： 1.Guangdong Acad Agr Sci, Guangdong Key Lab Agr Prod Proc, Sericultural & Agri Food Res Inst, Key Lab Funct Foods,Minist Agr & Rural Affairs, 133 Yiheng St,Dongguanzhuang Rd, Guangzhou 510610, Guangdong, Peoples R China
2.South China Univ Technol, Sch Food Sci & Engn, Guangdong Prov Key Lab Green Proc Nat Prod & Prod, 381 Wushan Rd, Guangzhou 510641, Guangdong, Peoples R China
关键词： Mulberry leaf; Oat bran; Hypoglycemic; Glucose metabolism; Gut microbiota; Combined effects
期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.451； 五年影响因子：4.907 ）
ISSN： 1756-4646
年卷期： 2019 年 61 卷
页码：
收录情况： SCI
摘要： The aim of this study was to investigate the combined effects of mulberry leaf and oat bran on type 2 diabetes. Co-treatment of diabetic mice with mulberry leaf and oat bran for 28 days led to lower glucose level and better glucose tolerance capacity than either mulberry leaf or oat bran treatment. It was found that this combination resulted in more significant inhibitory effects on alanine transaminase and aspartate transaminase activities. Meanwhile, the enhancement on insulin receptor and glucokinase expressions and down-regulation on pyruvate carboxylase, phosphoenolpyruvate carboxykinase, and pyruvate dehydrogenase complex kinase expressions were also observed. Additionally, the combination increased the gut microbiota diversity, and reshaped the gut microbiota structure. Based on the above data, it is more feasible to affirm that the combined supplementation of mulberry leaf and oat bran is a potential adjuvant on the treatment of diabetes mellitus.
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