Molecular characterization and expression analysis of the CCR9 gene from cobia (Rachycentron canadum) following bacterial and poly I:C challenge
文献类型： 外文期刊
作者： Su, Youlu 1 ; Deng, Yiqin 1 ; Cheng, Changhong 1 ; Ma, Hongling 1 ; Guo, Zhixun 1 ; Feng, Juan 1 ;
作者机构： 1.Chinese Acad Fishery Sci, South China Sea Fisheries Res Inst, Minist Agr & Rural Affairs, Key Lab South China Sea Fishery Resources Exploit, Guangzhou 510300, Guangdong, Peoples R China
2.Zhongkai Univ Agr & Engn, Guangdong Prov Water Environm & Aquat Prod Secur, Guangzhou Key Lab Aquat Anim Dis & Waterfowl Bree, Coll Anim Sci & Technol, Guangzhou, Guangdong, Peoples R China
关键词： Cobia (Rachycentron canadum); CC chemokine receptor 9 (CCR9); immune challenge; expression pattern
期刊名称：JOURNAL OF APPLIED ANIMAL RESEARCH （ 影响因子：1.63； 五年影响因子：1.727 ）
ISSN： 0971-2119
年卷期： 2019 年 47 卷 1 期
页码：
收录情况： SCI
摘要： Chemokine receptors play an important role in coordination of cell trafficking in many biological processes. In this study, a CC chemokine receptor 9 of cobia Rachycentron canadum (RcCCR9) was identified. Analysis of the ORF (1119 bp) of RcCCR9 revealed a predicted protein of 41.87 kDa with typical seven transmembrane domain architecture. RcCCR9 shared several conserved structural features with homologs from mammals and other fish, and had a consistent relationship with phylogenetic trees and sequence identities. Reverse transcription quantitative PCR analysis showed ubiquitous RcCCR9 transcripts in healthy cobia, mainly in immune-related organs, with the highest levels in blood and lower levels in intestines and brain. After challenge with inactivated Vibrio harveyi or viral mimic poly I:C, RcCCR9 expression was up-regulated in head kidney and down-regulated in spleen. Compared with poly I:C, V. harveyi induced a stronger up/down-regulation of CCR9 mRNA levels in the central immune organs. RcCCR9 seems to be strongly involved in host defense against bacterial infection.
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