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Effects of sinomenine in LPS-associated diseases are related to inhibition of LBP, Mac-1, and L-selectin levels

文献类型： 外文期刊

作者： Yang, Haifeng 1 ; Wang, Jing 1 ; Chen, Xiaolan 1 ; Jiang, Chunmao 1 ; He, Kongwang 2 ; Li, Bin 2 ; Hu, Yiyi 2 ;

作者机构： 1.Jiangsu Agrianim Husb Vocat Coll, Taizhou, Peoples R China

2.Jiangsu Acad Agr Sci, Inst Vet Med, Minist Sci & Technol, State Key Lab Cultivat,Jiangsu Key Lab Food Qual, 50 Zhong Ling St, Nanjing 210014, Jiangsu, Peoples R China

3.Yangzhou Univ, Jiangsu Coinnovat Ctr Prevent & Control Importa, Yangzhou, Jiangsu, Peoples R China

关键词： Inflammation; LBP; LPS; L-selectin; Mac-1; sinomenine

期刊名称：JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS （ 影响因子：1.786； 五年影响因子：1.7 ）

ISSN： 0140-7783

年卷期：

页码：

收录情况： SCI

摘要： The aim of the research was to investigate the anti-endotoxin and anti-inflammatory effects of Sinomenine, an agent commonly found in Chinese herbal medicines. Endotoxin (i.e., 1 mg lipopolysaccharide (LPS)/kg)) was administered via intraperitoneal (IP) injection to piglets in high-, middle-, and low-dose sinomenine groups. Piglets were then treated with 1, 5 or 10 mg/kg sinomenine, intramuscularly (i.m.), 3 hr after LPS. Vehicle was administered, as above, to drug control group piglets followed 3 hr later by 10 mg/kg sinomenine i.m.. LPS control group piglets were challenged with 1 mg/kg LPS IP, followed by vehicle i.m., and naive control piglets were treated with normal saline IP, followed by normal saline i.m., as above. Temperatures were measured, and blood samples were collected from the precaval veins of piglets at 12, 24, and 48 hr post-LPS or vehicle injection. Clinical signs were recorded, and index levels were analyzed via ELISA. Sinomenine was found to reduce the incidence and severity of LPS-induced toxicities, including body temperature elevation, cell adhesion, and systemic inflammation. These data suggest that sinomenine may be effective for regulating inflammatory responses and has the potential for use as an anti-endotoxin therapy.

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