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Cafestol and Kahweol: A Review on Their Bioactivities and Pharmacological Properties

文献类型： 外文期刊

作者： Ren, Yaqi 1 ; Wang, Chunlan 2 ; Xu, Jiakun 2 ; Wang, Shuaiyu 1 ;

作者机构： 1.China Agr Univ, Coll Vet Med, Beijing 100193, Peoples R China

2.Chinese Acad Fishery Sci, Key Lab Sustainable Dev Polar Fisheries, Minist Agr & Rural ff airs, Yellow Sea Fisheries Res Inst, Qingdao 266071, Shandong, Peoples R China

3.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Byprod, Qingdao 266071, Shandong, Peoples R China

关键词： cafestol; kahweol; serum lipid; anti-inflammation; anti-tumor; anti-diabetes

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：5.923； 五年影响因子：6.132 ）

ISSN：

年卷期： 2019 年 20 卷 17 期

页码：

收录情况： SCI

摘要： Cafestol and kahweol are natural diterpenes extracted from coffee beans. In addition to the effect of raising serum lipid, in vitro and in vivo experimental results have revealed that the two diterpenes demonstrate multiple potential pharmacological actions such as anti-inflammation, hepatoprotective, anti-cancer, anti-diabetic, and anti-osteoclastogenesis activities. The most relevant mechanisms involved are down-regulating inflammation mediators, increasing glutathione (GSH), inducing apoptosis of tumor cells and anti-angiogenesis. Cafestol and kahweol show similar biological activities but not exactly the same, which might due to the presence of one conjugated double bond on the furan ring of the latter. This review aims to summarize the pharmacological properties and the underlying mechanisms of cafestol-type diterpenoids, which show their potential as functional food and multi-target alternative medicine.

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