文献类型： 外文期刊
作者： Yuan, Chao 1 ; Yang, Hong-Xia 2 ; Guo, Yu-Hua 3 ; Fan, Lin 4 ; Zhang, Ying-Bo 1 ; Li, Gang 2 ;
作者机构： 1.CATAS, Trop Crops Genet Resources Inst, Haikou 571101, Hainan, Peoples R China
2.Qingdao Univ, Sch Pharm, Dept Nat Med Chem & Pharmacognosy, Qingdao 266021, Shandong, Peoples R China
3.Shandong Drug & Food Vocat Coll, Weihai 264210, Shandong, Peoples R China
4.Weihai Vocat Coll, Weihai 264210, Peoples R China
期刊名称：RSC ADVANCES （ 影响因子：3.361； 五年影响因子：3.39 ）
ISSN：
年卷期： 2019 年 9 卷 47 期
页码：
收录情况： SCI
摘要： Four new alpha-pyrones, hypotiens A-D (1-4), were isolated from a fungal endophyte, Hypoxylon investiens J2, harbored in the medicinal plant Blumea balsamifera. Their structures were determined through detailed HRMS and NMR spectroscopic data. Compounds 1-4 are new alpha-pyrone derivatives containing an unusual dimethyl substitution in the highly unsaturated side chain. Their plausible biosynthetic pathway was discussed. Biological assay indicated that compounds 1-4 showed no antimicrobial, quorum sensing inhibitory, and cytotoxic activities. The specific side chain in alpha-pyrone derivatives 1-4 might be responsible for the weak pharmacological activities.
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