Antioxidant and Hypolipidemic Activities of Acid-Depolymerised Exopolysaccharides by Termitomyces albuminosus
文献类型： 外文期刊
作者： Zhao, Huajie 1 ; Wang, Xiuxiu 2 ; Liu, Xinchao 2 ; Zhang, Jianjun 2 ; Wan, Luzhang 1 ; Jia, Le 2 ;
作者机构： 1.Shandong Acad Agr Sci, Inst Agr Resources & Environm, Jinan 250100, Shandong, Peoples R China
2.Shandong Agr Univ, Coll Life Sci, Tai An 271018, Shandong, Peoples R China
期刊名称：OXIDATIVE MEDICINE AND CELLULAR LONGEVITY （ 影响因子：6.543； 五年影响因子：7.454 ）
ISSN： 1942-0900
年卷期： 2019 年 2019 卷
页码：
收录情况： SCI
摘要： The acid-depolymerised exopolysaccharides (ADES) of Termitomyces albuminosus were obtained, and the major fraction of ADES1 was isolated and purified by DEAE-52 cellulose anion-exchange column chromatography. Physicochemical characterizations showed that ADES1 was an alpha- and a beta-configuration with the molecular weight of 2.43 kDa, containing (1 -> 3, 4)-linked-Glcp, (1 -> 4)-linked-D-Glcp, (1 -> 3)-linked-D-Xylp, (1 -> 4)-linked-D-Manp, T-Glcp, (1 -> 6)-linked-D-Galp, and (1 -> 4)-linked-L-Arap. The in vivo assays showed that ADES1 could reduce lipid levels in the serum and liver, decrease serum enzyme activities, and improve antioxidant enzyme activities and p-AMPK alpha expressions in hyperlipidemic mice, which were also confirmed by histopathological observations. These data indicated that ADES1 might be considered as a novel substance to treat and prevent hyperlipidemia and as a hepatoprotective agent.
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