Mycelium Polysaccharides from Termitomyces albuminosus Attenuate CCl4-Induced Chronic Liver Injury Via Inhibiting TGF beta 1/Smad3 and NF-kappa B Signal Pathways
文献类型： 外文期刊
作者： Zhao, Huajie 1 ; Li, Huaping 2 ; Feng, Yanbo 2 ; Zhang, Yiwen 2 ; Yuan, Fangfang 2 ; Zhang, Jianjun 2 ; Ren, Haixia 1 ; J 1 ;
作者机构： 1.Shandong Acad Agr Sci, Inst Agr Resources & Environm, Jinan 250100, Shandong, Peoples R China
2.Shandong Agr Univ, Coll Life Sci, Tai An 271018, Shandong, Peoples R China
关键词： anti-oxidation; anti-inflammatory; anti-fibrosis; liver injury; mycelium polysaccharides; Termitomyces albuminosus
期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：5.923； 五年影响因子：6.132 ）
ISSN：
年卷期： 2019 年 20 卷 19 期
页码：
收录情况： SCI
摘要： A major fraction (MPT-W), eluted by deionized water, was extracted from mycelium polysaccharides of Termitomyces albuminosus (MPT), and its antioxidant, anti-fibrosis, and anti-inflammatory activities in CCl4-induced chronic liver injury mice, as well as preliminary characterizations, were evaluated. The results showed that MPT-W was a polysaccharide of alpha- and beta-configurations containing xylose (Xyl), fucose (Fuc), mannose (Man), galactose (Gal), and glucose (Glc) with a molar ratio of 0.29:8.67:37.89:35.98:16.60 by gas chromatography-mass spectrometry (GC-MS), Fourier transform infrared (FT-IR) spectroscopy. Its molecular weight (Mw), obtained by high-performance gel permeation chromatography (HPGPC), was 1.30 x 10(5) Da. The antioxidant assays in vitro showed that MPT-W displayed scavenging free-radical abilities. Based on the data of in vivo experiments, MPT-W could inhibit TGF beta 1/Smad3 and NF-kappa B pathways; decrease the level and activity of cytochrome P4502E1 (CYP2E1), malonaldehyde (MDA) and serum enzyme; activate the HO-1/Nrf2 pathway; and increase antioxidant enzymes to protect the liver in CCl4-induced chronic liver injury mice. Therefore, MPT-W could be a potentially natural and functional resource contributing to antioxidant, hepatoprotective, and anti-inflammatory effects with potential health benefits.
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