Antioxidant Activity and Protective Effects of Enzyme-Extracted Oudemansiella radiata Polysaccharides on Alcohol-Induced Liver Injury
文献类型： 外文期刊
作者： Wang, Xiuxiu 2 ; Liu, Min 2 ; Zhang, Chen 2 ; Li, Shangshang 2 ; Yang, Qihang 2 ; Zhang, Jianjun 2 ; Gong, Zhiyuan 1 ; Ha 1 ;
作者机构： 1.Shandong Acad Agr Sci, Inst Agr Resources & Environm, Key Lab Wastes Matrix Utilizat, Minist Agr, Jinan 250100, Shandong, Peoples R China
2.Shandong Agr Univ, Coll Life Sci, Tai An 271018, Shandong, Peoples R China
关键词： enzyme-extracted Oudemansiella radiata polysaccharides; antioxidant; hepatoprotective effects; alcoholic liver diseases
期刊名称：MOLECULES （ 影响因子：4.411； 五年影响因子：4.587 ）
ISSN： 1420-3049
年卷期： 2018 年 23 卷 2 期
页码：
收录情况： SCI
摘要： This work was to examine the antioxidation in vitro and hepatoprotective effects of enzyme-extracted Oudemansiella radiata polysaccharides (En-OPS) on alcohol-induced liver damage in mice. The antioxidant activities were determined according to the scavenging effects of En-OPS on hydroxyl, superoxide, and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals, and the level of reducing power. En-OPS showed hepatoprotective activities on decreasing the serum levels of aspertate aminotransferase (AST), alamine aminotransferase (ALT), and alkaline phosphatase (ALP), as well as hepatic lipid levels of total cholesterol (TC) and triacylglycerols (TG). En-OPS treatment reversed the acute impairment induced by alcohol consumption, including reactive oxygen species (ROS) generation, malondialdehyde (MAD), and lipid peroxide (LPO) elevation; and superoxide dismutase (SOD), GSH peroxide (GSH-Px), catalase (CAT), and total antioxidant capacity (T-AOC) impairment. The En-OPS effectively ameliorated alcohol metabolism by activating alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), and reducing cytochrome P450 2E1 (CYP2E1) levels. Furthermore, the histopathological observations also displayed that En-OPS could alleviate liver damage. These results indicated that En-OPS could be suitable to be an ingredient of preventing alcoholic liver diseases (ALD). In addition, the preliminary structure characteristics of En-OPS were also analyzed by Fourier transform infrared (FT-IR) spectroscopy and a gas chromatography-flame ionization detector (GC-FID).
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