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Efficiently Anti-Obesity Effects of Unsaturated Alginate Oligosaccharides (UAOS) in High-Fat Diet (HFD)-Fed Mice

文献类型： 外文期刊

作者： Li, Shangyong 1 ; He, Ningning 1 ; Wang, Linna 2 ;

作者机构： 1.Qingdao Univ, Coll Basic Med, Dept Pharmacol, Qingdao 266071, Shandong, Peoples R China

2.Chinese Acad Fishery Sci, Minist Agr, Key Lab Sustainable Dev Marine Fisheries, Yellow Sea Fisheries Res Inst, Qingdao 266071, Shandong, Peoples R China

关键词： unsaturated alginate oligosaccharides; hepatoprotective effect; anti-oxidant activity; anti-obesity activity

期刊名称：MARINE DRUGS （ 影响因子：5.118； 五年影响因子：5.951 ）

ISSN：

年卷期： 2019 年 17 卷 9 期

页码：

收录情况： SCI

摘要： Obesity and its related complications have become one of the leading problems affecting human health. However, current anti-obesity treatments are limited by high cost and numerous adverse effects. In this study, we investigated the use of a non-toxic green food additive, known as unsaturated alginate oligosaccharides (UAOS) from the enzymatic degradation of Laminaria japonicais, which showed effective anti-obesity effects in a high-fat diet (HFD) mouse model. Compared with acid hydrolyzed saturated alginate oligosaccharides (SAOS), UAOS significantly reduced body weight, serum lipid, including triacylglycerol (TG), total cholesterol (TC) and free fatty acids (FFA), liver weight, liver TG and TC, serum alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels, adipose mass, reactive oxygen species (ROS) formation, and accumulation induced in HFD mice. Moreover, the structural differences in beta-d-mannuronate (M) and its C5 epimer alpha-l-guluronate (G) did not cause significant functional differences. Meanwhile, UAOS significantly increased both AMP-activated protein kinase alpha (AMPK alpha) and acetyl-CoA carboxylase (ACC) phosphorylation in adipocytes, which indicated that UAOS had an anti-obesity effect mainly through AMPK signaling. Our results indicate that UAOS has the potential for further development as an adjuvant treatment for many metabolic diseases such as fatty liver, hypertriglyceridemia, and possibly diabetes.

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