Anti-oxidative, anti-inflammatory and hepatoprotective effects of Radix Bupleuri extract against oxidative damage in tilapia (Oreochromis niloticus) via Nrf2 and TLRs signaling pathway
文献类型： 外文期刊
作者： Jia, Rui 1 ; Gu, Zhengyan 1 ; He, Qin 1 ; Du, Jinliang 2 ; Cao, Liping 2 ; Jeney, Galina 3 ; Xu, Pao 1 ; Yin, Guojun 1 ;
作者机构： 1.Nanjing Agr Univ, Wuxi Fisheries Coll, Wuxi 214081, Jiangsu, Peoples R China
2.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Minist Agr & Rural Affairs, Key Lab Freshwater Fisheries & Germplasm Resource, Wuxim 214081, Peoples R China
3.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Int Joint Res Lab Fish Immunopharmacol, Wuxi 214081, Jiangsu, Peoples R China
4.Natl Agr Res Ctr, Res Inst Fisheries & Aquaculture, Anna Light 8, H-5440 Szarvas, Hungary
关键词： Radix bupleuri extract; Erythroid 2-related factor 2; Toll-like receptor; Anti-Oxidative effect; Oreochromis niloticus
期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：4.581； 五年影响因子：4.851 ）
ISSN： 1050-4648
年卷期： 2019 年 93 卷
页码：
收录情况： SCI
摘要： Radix Bupleuri extract (RBE) is one of the most popular oriental herbal medicines, which has anti-oxidative and anti-inflammatory properties. However, its protective effects and underlying molecular mechanisms on oxidative damage in tilapia are still unclear. The aims of the study were to explore the anti-oxidative, anti-inflammatory and hepatoprotective effects of RBE against oxidative damage, and to elucidate underlying molecular mechanisms in fish. Tilapia received diet containing three doses of RBE (0, 1 and 3 g/kg diet) for 60 days, and then were given an intraperitoneal injection of H2O2 or saline. Before injection, RBE treatments improved growth performance and partial anti-oxidative capacity in tilapia. After oxidative damage, RBE pretreatments were able to signally reduce the higher serum aminotransferases, alkaline phosphatase (AKP) and liver necrosis. In serum and liver, the abnormal lipid peroxidation level and antioxidant status induced by H2O2 injection were restored by RBE treatments. Furthermore, RBE treatments activated erythroid 2-related factor 2 (Nrf2) signaling pathway, which promoted the gene expression of heme oxygenase 1 (HO-1), NAD(P) H:quinone oxidoreductase 1 (NQO-1), glutathione-S-transferase (GST) and catalase (CAT). Meanwhile, RBE treatments reduced inflammatory response by inhibiting TLRs-MyD88-NF-kappa B signaling pathway, accompanied by the lower interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha) and IL-8 mRNA levels. In addition, RBE treatments upregulated complement (C3) gene expression and downregulated heat shock protein (HSP70) gene expression. In conclusion, the current study suggested that RBE pretreatments protected against H2O2-induced oxidative damage in tilapia. The beneficial activity of RBE may be due to the modulation of Nrf2/ARE and TLRs-Myd88-NF-kappa B signaling pathway.
- 相关文献
作者其他论文 更多>>
-
Polystyrene nanoplastics amplify the toxic effects of PFOA on the Chinese mitten crab (Eriocheir sinensis)
作者：Huang, Peng;Cao, Liping;Du, Jinliang;Guo, Yiqing;Xu, Gangchun;Gao, Jiancao;Cao, Liping;Du, Jinliang;Li, Quanjie;Sun, Yi;Zhu, Haojun;Xu, Gangchun;Gao, Jiancao
关键词：NPs; PFAS; Aquatic crustacean; Multi-omics; Combined toxicity
-
Effects of starvation-refeeding on antioxidant status, metabolic function, and adaptive response in the muscle of Cyprinus carpio
作者：Feng, Wenrong;Li, Jianlin;Xu, Yuanfeng;Jiang, Gang;Su, Shengyan;Jia, Rui;Tang, Yongkai;Zhang, Zhihua
关键词：Starvation; Oxidative stress; Mitophagy; FoxO signaling pathway; Cyprinus carpio
-
Oxidative Stress Disrupts Gill Function in Eriocheir sinensis: Consequences for Ion Transport, Apoptosis, and Autophagy
作者：Feng, Wenrong;He, Qinghong;Xu, Yuanfeng;Jiang, Gang;Li, Jianlin;Jia, Rui;Tang, Yongkai;Feng, Wenrong;Jia, Rui;Tang, Yongkai;Yang, Qiqin;Zhou, Jun
关键词：
Eriocheir sinensis ; oxidation; osmoregulation and ion regulation; MAPK; AMPK -
Study on the Toxicological Impacts of Intraperitoneal Microcystin-LR Injection on GIFT Tilapia (Oreochromis niloticus) Through Multi-Omics Analysis
作者：Wu, Haizheng;Du, Jinliang;Cao, Liping;Xu, Gangchun;Zhu, Haojun;Li, Quanjie;Gao, Jiancao;Du, Jinliang;Cao, Liping;Sun, Yi;Xu, Gangchun
关键词：microcystin-LR; GIFT tilapia; oxidative stress; intestinal microbiota; SCFAs
-
Multi-omics and biochemical analyses provide insights into hepatic glucolipid metabolism in red tilapia ( Oreochromis spp.) under salinity stress
作者：Jiang, Bingjie;Tao, Yifan;Lu, Siqi;Hua, Jixiang;Li, Yan;Dong, Yalun;Xu, Pao;Qiang, Jun;Huang, Renshan;Xu, Pao;Qiang, Jun
关键词：Glucolipid metabolism; Multi-omics; Physiological response; Red tilapia; Salinity stress
-
Genome-Wide Association Study and RNA-Seq Analysis Uncover Candidate Genes Controlling Growth Traits in Red Tilapia (Oreochromis spp.) Under Hyperosmotic Stress
作者：Jiang, Bingjie;Tao, Yifan;Lu, Siqi;Xu, Pao;Qiang, Jun;Liu, Kai;Tao, Wenjing;Badran, Mohamed Fekri;Saleh, Moustafa Hassan Lotfy;Aboueleila, Rahma Halim Mahmoud;Xu, Pao;Qiang, Jun;Liu, Kai
关键词：red tilapia; growth traits; RNA-seq; GWAS; candidate gene
-
Immune response of intestinal micrornas to transport stress in hybrid yellow catfish (tachysurus fulvidraco♀ xt. vachellii♂) : response strategy and potential biomarker
作者：Zheng, Tao;Zheng, Tao;Qiang, Jun;Xu, Pao;Zheng, Tao;Tao, Yifan;Lu, Siqi;Qiang, Jun;Xu, Pao
关键词：Transport stress; Intestine; Immune regulation; Hybrid yellow catfish; RNA sequencing
