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Effects of silkworm pupa protein hydrolysates on mitochondrial substructure and metabolism in gastric cancer cells

文献类型： 外文期刊

作者： Li, Weixin 1 ; Mu, Lixia 1 ; Wu, Leiyan 2 ; Zou, Yuxiao 1 ; Zhao, Haifeng 3 ; Liao, Sentai 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Sericultural & Agrifood Res Inst, Key Lab Funct Foods, Minist Agr,Guangdong Key Lab Agr Prod Proc, Guangzhou 510610, Guangdong, Peoples R China

2.Jiangxi Agr Univ, Sch Food Sci & Engn, Nanchang 330045, Jiangxi, Peoples R China

3.South China Univ Technol, Sch Food Sci & Engn, Guangzhou 510640, Guangdong, Peoples R China

关键词： Silkworm pupa protein hydrolysates; Cell viability; Organelle; Mitochondrial metabolic pathway

期刊名称：JOURNAL OF ASIA-PACIFIC ENTOMOLOGY （ 影响因子：1.303； 五年影响因子：1.427 ）

ISSN： 1226-8615

年卷期： 2019 年 22 卷 2 期

页码：

收录情况： SCI

摘要： The effects of silkworm pupa protein hydrolysates (SPPHs) on the apoptosis of MGC-803 gastric cancer cells were investigated in this study. The role of mitochondrial-dependent apoptosis in SPPHs-dependent inhibition of MGC-803 cell viability was also explored. SPPH5 were found to induce apoptosis in MGC-803 cells with an IC50 of 0.30 mg/ml. A series of changes in cellular organelle structural were observed during MGC-803 cell apoptosis that included mitochondrial swelling, vacuolation and rupture. These changes may ultimately impact on metabolic energy supply in MGC-803 cells. The expression of the pro- and anti-apoptotic proteins Bcl-2 and Bax, and the activation of cytochrome c (Cyt C), Caspase-3 and Caspase-9 were altered following induction of apoptosis by SPPH5 in MGC-803 cells. Moreover, the increase in the ratio of Bax to Bcl-2 expression is known to play an important role in the activation of the mitochondrial-dependent apoptotic pathway.

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