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Long-term effect of early antibiotic exposure on amino acid profiles and gene expression of transporters and receptors in the small intestinal mucosa of growing pigs with different dietary protein levels

文献类型： 外文期刊

作者： Yu, Miao 1 ; Mu, Chunlong 1 ; Zhang, Chuanjian 1 ; Yang, Yuxiang 1 ; Su, Yong 1 ; Zhu, Weiyun 1 ;

作者机构： 1.Nanjing Agr Univ, Coll Anim Sci & Technol, Natl Ctr Int Res Anim Gut Nutr, Lab Gastrointestinal Microbiol,Jiangsu Key Lab Ga, Nanjing, Jiangsu, Peoples R China

2.Guangdong Acad Agr Sci, Inst Anim Sci, Key Lab Anim Nutr & Feed Sci South China,State Ke, Minist Agr,Guangdong Publ Lab Anim Breeding & Nut, Guangzhou, Guangdong, Peoples R China

关键词： antibiotic; amino acid profiles; amino acid receptor; amino acid transporter; growing pigs; low-CP diet

期刊名称：JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE （ 影响因子：3.638； 五年影响因子：3.802 ）

ISSN： 0022-5142

年卷期： 2020 年 100 卷 1 期

页码：

收录情况： SCI

摘要： BACKGROUND This study evaluated the effects of early antibiotic exposure (EAE) on subsequent amino acid (AA) profiles and small intestinal AA transporter and receptor expression level in pigs with different dietary crude protein (CP) levels. Eighteen litters of piglets were fed creep feed diets, either with or without antibiotics while with sow on day 7. The pigs were weaned at day 23 and fed the same diets until day 42, when random pigs within each group were offered a normal- or low-CP diet, thereby creating four groups. On day 120, the pigs were euthanized, and jejunal and ileal mucosa and digesta were collected for gene-expression and AA-concentration analysis. RESULTS With the normal-CP diet, EAE increased (P < 0.05) the concentrations of six essential amino acids (EAA) and three non-essential amino acids (NEAA) in serum, four EAAs and four NEAAs in jejunal mucosa, one EAA and two NEAAs in ileal mucosa, five EAAs and three NEAAs in jejunal digesta, and three EAAs and two NEAAs in ileal digesta. Early antibiotic exposure upregulated (P < 0.05) CAT1, ASCT2, ATB(0,+), CaSR, T1R1, and T1R3 expression in the jejunum, downregulated PepT1 expression with a normal-CP diet. It upregulated (P < 0.05) the expressions of CAT1, ATB(0,+), ATP1A1, and T1R3 in the ileum with a normal-CP diet. CONCLUSION These results suggest that EAE has long-term effects on AA profiles, mainly in the jejunum and serum, by increasing AA transporter expression in the intestine, and that these effects may be influenced by dietary CP levels. (c) 2019 Society of Chemical Industry

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