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1-Deoxynojirimycin modulates glucose homeostasis by regulating the combination of IR-GlUT4 and ADIPO-GLUT4 pathways in 3T3-L1 adipocytes

文献类型： 外文期刊

作者： Li, Qian 1 ; Wang, Yiguo 1 ; Dai, Yanli 1 ; Shen, Weizhi 1 ; Liao, Sentai 1 ; Zou, Yuxiao 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Sericultural & Agri Food Res Inst, Guangdong Key Lab Agr Prod Proc, Key Lab Funct Foods,Minist Agr & Rural Affairs, Yiheng Rd 133, Guangzhou 510610, Guangdong, Peoples R China

关键词： AMPK; DNJ; Glucose homeostasis; GLUT4

期刊名称：MOLECULAR BIOLOGY REPORTS （ 影响因子：2.316； 五年影响因子：2.357 ）

ISSN： 0301-4851

年卷期： 2019 年 46 卷 6 期

页码：

收录情况： SCI

摘要： 1-Deoxynojirimycin (DNJ), the main alkaloid in mulberry leaves, was recognized to treat patients with type 2 diabetes mellitus (T2DM). However, the regulatory mechanism of DNJ on glucose homeostasis was still unclear. In the present study, a safe concentration of 0.1-10 mu mol/L for DNJ was incubated with mature 3T3-L1 adipocytes. The results demonstrated that the genes/proteins expression of insulin receptor (IR), phosphatidylinositol-3-kinase (PI3K), protein kinase B (AKt/PkB), and adiponectin (ADIPO) increased with the increasing of DNJ concentration from 0.1-10 mu mol/L. However the mRNA expression of adenosine 5 '-monophosphate (AMP)-activated protein kinase (AMPK), glucose transporter 4 (GLUT4) and glucose absorption increased to the maximum at concentration of 5 mu mol/L then decreased with further increase of DNJ concentration to 10 mu mol/L. Both IR and ADIPO signaling pathways simultaneously affect the glucose homeostasis regulation effect of DNJ, whereas the key response target located in AMPK and its effect on subsequent GLUT4 mRNA expression.

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