文献类型： 外文期刊
作者： Wu, Luyin 1 ; Ru, Huijun 1 ; Ni, Zhaohui 1 ; Zhang, Xiaoxin 2 ; Xie, Huaxiao 1 ; Yao, Fan 1 ; Zhang, He 4 ; Li, Yunfeng 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Observat Stn Fishery Resource & Environm Upper Mi, Minist Agr, Wuhan 430223, Hubei, Peoples R China
2.Beijing Normal Univ, Sch Environm, State Key Lab Water Environm Simulat, Beijing 100875, Peoples R China
3.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China
4.Wenzhou Med Univ, Sch Optometry & Ophthalmol, State Key Lab Optometry Ophthalmol & Visual Sci, Wenzhou 325003, Zhejiang, Peoples R China
5.Wenzhou Med Univ, Hosp Eye, Wenzhou 325003, Zhejiang, Peoples R China
关键词： DDTs; DDE; Hypothalamic-pituitary-thyroid axis; Thyroid disruption
期刊名称：AQUATIC TOXICOLOGY （ 影响因子：4.964； 五年影响因子：5.071 ）
ISSN： 0166-445X
年卷期： 2019 年 216 卷
页码：
收录情况： SCI
摘要： 1,1-Trichloro-2-(p-chlorophenyl)-2-(o-chlorophenyl) ethane (o,p'-DDT) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE) cause thyroid disruption, but the underlying mechanisms of these disturbances in fish remain unclear. To explore the potential mechanisms of thyroid dysfunction caused by o,p'-DDT and p,p'-DDE, thyroid hormone and gene expression levels in the hypothalamic-pituitary-thyroid (HPT) axis were measured, and the developmental toxicity were recorded in zebrafish larvae. Zebrafish embryos/larvae were exposed to o,p'-DDT (0, 0.28, 2.8, and 28 nM; or 0, 0.1, 1, and 10 mu g/L) and p,p'-DDE (0, 1.57, 15.7, and 157 nM; or 0, 0.5, 5, and 50 mu g/L) for 7 days. The genes related to thyroid hormone synthesis (crh, tsh beta, tg, nis and tpo) and thyroid development (nkx2.1 and pax8) were up-regulated in both the o,p'-DDT and p,p'-DDE exposure groups. Zebrafish embryos/larvae exposed to o,p'-DDT showed significantly increased total whole-body T4 and T3 levels, with the expression of ugt1ab and dio3 being significantly down-regulated. However, the p,p'-DDE exposure groups showed significantly lowered whole-body total T4 and T3 levels, which were associated with up-regulation and down-regulation expression of the expression of dio2 and ugt1ab, respectively. Interestingly, the ratio of T3 to T4 was significantly decreased in the o,p'-DDT (28 nM) and p,p'-DDE (157 nM) exposure groups, suggesting an impairment of thyroid function. In addition, reduced survival rates and body lengths and increased malformation rates were recorded after treatment with either o,p'-DDT or p,p'-DDE. In summary, our study indicates that the disruption of thyroid states was different in response to o,p'-DDT and p,p'-DDE exposure in zebrafish larvae.
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