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Effects of low concentrations of triphenyltin on neurobehavior and the thyroid endocrine system in zebrafish

文献类型： 外文期刊

作者： Li, Ping 1 ; Li, Zhi-Hua 1 ; Zhong, Liqiao 2 ;

作者机构： 1.Shandong Univ, Marine Coll, Weihai 264209, Peoples R China

2.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Wuhan 430223, Hubei, Peoples R China

关键词： Triphenyltin; Neurobehavior; Thyroid system; Zebrafish

期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：6.291； 五年影响因子：6.393 ）

ISSN： 0147-6513

年卷期： 2019 年 186 卷

页码：

收录情况： SCI

摘要： In the present study, to evaluate neurobehavioral toxicity and the thyroid-disrupting effects of environmental levels of triphenyltin (TPT), the zebrafish larvae were exposed to 1, 10 and 100 ng/l TPT. In the neurobehavioral assay, increased levels of dopamine and serotonin, decreased content of nitric oxide, inhibited activities of acetylcholinesterase and monoamine oxidase were observed in the whole body of zebrafish larvae after TPT treatment, as well as the serious abnormal non-reproductive behavior. Moreover, the whole-body the T4 levels were markedly decreased significantly, whereas T3 levels were not significantly changed under TPT stress. In addition, TPT exposure significantly changed the expression levels of genes related to thyroid system, including corticotropin-releasing hormone gene crh, thyroid-stimulating hormone gene tsh beta, thyroglobulin gene tg, sodium/iodide symporter gene nis, thyroid hormone nuclear receptor Era, isoform tr beta, types I deiodinase gene dio1and types Il deiodinase gene dio2. The regulated responsiveness of thyroid hormone and related genes expression levels suggested that TPT could induce the thyroid disrupting effects in zebrafish larvae. Therefore, our results provide new aspects of TPT as an endocrine disrupting chemical.

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