Lactobacillus plantarum DP189 prevents cognitive dysfunction in D-galactose/AlCl3 induced mouse model of Alzheimer's disease via modulating gut microbiota and PI3K/Akt/GSK-3 beta signaling pathway
文献类型： 外文期刊
作者： Song, Xinping 1 ; Zhao, Zijian 1 ; Zhao, Yujuan 1 ; Wang, Zhiguo 2 ; Wang, Chao 1 ; Yang, Ge 1 ; Li, Shengyu 1 ;
作者机构： 1.Jilin Acad Agr Sci, Inst Agrofood Technol, 1363 Sheng Tai St, Changchun 130033, Jilin, Peoples R China
2.Gen Hosp Northern Theater Command, Dept Nucl Med, Shenyang, Peoples R China
3.Yanbian Univ, Coll Agr, Yanji, Peoples R China
关键词： Lactobacillus plantarum; Alzheimer's disease; gut microbiota; GSK-3 beta; PI3K; microbiota-gut-brain axis; cognitive dysfunction; probiotics
期刊名称：NUTRITIONAL NEUROSCIENCE （ 影响因子：5.0； 五年影响因子：4.657 ）
ISSN： 1028-415X
年卷期：
页码：
收录情况： SCI
摘要： Probiotic intervention has beneficial effects on host brain function and behavior via regulating microbiota-gut-brain axis; however, the underlying mechanism is not yet understood. Herein, we investigated that the effects of Lactobacillus plantarum DP189 (DP189) administration in preventing cognitive dysfunction and pathology of Alzheimer's disease (AD) in D-galactose (D-gal) and AlCl3-induced AD model mice. After L. plantarum DP189 intervention for 10 weeks, we assessed cognitive behavior, neurotransmitter expression, histological changes, microbial communities, and the mechanisms underlying the disease in AD model mice. The results showed that L. plantarum DP189 intervention prevented cognitive dysfunction by behavioral test. Increased levels of serotonin, dopamine, and gamma-aminobutyric acid positively affected the pathological processes by ameliorating neuronal damage, beta-amyloid deposition, and tau pathology. L. plantarum DP189 intervention simultaneously modulated the gut microbial communities to alleviate gut dysbiosis. Moreover, L. plantarum DP189 inhibited tau hyperphosphorylation by regulating the PI3 K/Akt/GSK-3 beta pathway. These findings indicated that L. plantarum DP189 intervention is a promising therapeutic strategy to prevent the onset and development of AD.
- 相关文献
作者其他论文 更多>>
-
Utilization of hyaluronic acid to improve Mozzarella cheese: Composition, texture, microstructure, and pizza baking properties
作者：Jiao, Yufu;Gao, Lei;Kang, You;Gao, Yansong;Zhao, Yujuan;Zhao, Zijian;Yang, Ge;Li, Shengyu;Jiao, Yufu;Gao, Lei;Kang, You;Gao, Yansong;Zhao, Yujuan;Zhao, Zijian;Yang, Ge;Li, Shengyu
关键词：Hyaluronic acid; Mozzarella cheese; Physicochemical; Microstructure; Pizza bake
-
Psoralen and Isopsoralen Activate Nuclear Factor Erythroid 2-Related Factor 2 Through Interaction With Kelch-Like ECH-Associated Protein 1
作者：Lv, Chengyu;Wang, Song;Sun, Chang;Chen, Yihao;Wang, Chao;Yuan, Cuiping;Qin, Fengxian;Li, Tiezhu;Liu, Jing
关键词：antioxidant response element; isopsoralen; molecular docking; Nrf2; psoralen
-
Anti-colorectal cancer effect of total minor ginsenosides produced by lactobacilli transformation of major ginsenosides by inducing apoptosis and regulating gut microbiota
作者：Shen, Yunjiao;Gao, Yansong;Yang, Ge;Zhao, Zijian;Zhao, Yujuan;Gao, Lei;Li, Shengyu;Shen, Yunjiao
关键词：ginsenoside; lactic acid bacteria; minor ginsenosides; apoptosis; anti-cancer; gut microbiota
-
Optimization of Tropane Alkaloids Extraction from Anisodus luridus Utilizing Response Surface Methodology and Quality Assessment through UPLC Fingerprinting
作者：Zhang, Baoxin;Jiang, Na;Xie, Hongjun;Lan, Xiaozhong;Zhang, Baoxin;Tian, Jingqin;Jiang, Na;Chai, Guozhu;Quan, Hong;Han, Xinghao;Lan, Xiaozhong;Zhang, Fangyuan;Liao, Zhihua;Chen, Min;Wang, Chao
关键词：
-
Transformation of Ginsenosides by Lactiplantibacillus plantarum MB11 Fermentation: Minor Ginsenosides Conversion and Enhancement of Anti-Colorectal Cancer Activity
作者：Shen, Yunjiao;Gao, Yansong;Yang, Ge;Zhao, Zijian;Zhao, Yujuan;Gao, Lei;Li, Shengyu;Shen, Yunjiao;Zhao, Lei
关键词：probiotic; Lactiplantibacillus plantarum; anticancer; ginsenosides; apoptosis; autophagy
-
Cellulase with Bacillus velezensis improves physicochemical characteristics, microbiota and metabolites of corn germ meal during two-stage co-fermentation
作者：Chen, Long;Guo, Yang;Liu, Xin;Zheng, Lin;Wei, Bingdong;Zhao, Zijian
关键词：Nutritional value; Two-stage solid-state fermentation; Microbial diversity; Fermented feed
-
Increasing minor ginsenosides contents and enhancing neuroprotective effects of total ginsenosides fermented by Lactiplantibacillus plantarum
作者：Yang, Ge;Gao, Yansong;Gao, Lei;Zhao, Zijian;Zhao, Yujuan;Wang, Chao;Li, Shengyu;Li, Shengyu
关键词：Minor ginsenosides; Lactiplantibacillus plantarum; Biotransformation; Neuroprotection; Inflammation; Apoptosis
