Microarray and metabolome analysis of hepatic response to fasting and subsequent refeeding in zebrafish (Danio rerio)
文献类型： 外文期刊
作者： Jia, Jirong 1 ; Qin, Jingkai 1 ; Yuan, Xi 1 ; Liao, Zongzhen 1 ; Huang, Jinfeng 1 ; Wang, Bin 1 ; Sun, Caiyun 1 ; Li, Wen 1 ;
作者机构： 1.Sun Yat Sen Univ, Guangdong Prov Key Lab Aquat Econ Anim, Guangdong Prov Engn Technol Res Ctr Hlth Breeding, Sch Life Sci, 135 Xingang West Rd, Guangzhou 510275, Guangdong, Peoples R China
2.Chinese Acad Fishery Sci, Key Lab Sustainable Dev Marine Fisheries, Yellow Sea Fisheries Res Inst, Minist Agr, Qingdao 266071, Shandong, Peoples R China
期刊名称：BMC GENOMICS （ 影响因子：3.969； 五年影响因子：4.478 ）
ISSN： 1471-2164
年卷期： 2019 年 20 卷 1 期
页码：
收录情况： SCI
摘要： BackgroundCompensatory growth refers to the phenomenon in which organisms grow faster after the improvement of an adverse environment and is thought to be an adaptive evolution to cope with the alleviation of the hostile environment. Many fish have the capacity for compensatory growth, but the underlying cellular mechanisms remain unclear. In the present study, microarray and nontargeted metabolomics were performed to characterize the transcriptome and metabolome of zebrafish liver during compensatory growth.ResultsZebrafish could regain the weight they lost during 3weeks of fasting and reach a final weight similar to that of fish fed ad libitum when refed for 15days. When refeeding for 3days, the liver displayed hyperplasia accompanied with decreased triglyceride contents and increased glycogen contents. The microarray results showed that when food was resupplied for 3days, the liver TCA cycle (Tricarboxylic acid cycle) and oxidative phosphorylation processes were upregulated, while DNA replication and repair, as well as proteasome assembly were also activated. Integration of transcriptome and metabolome data highlighted transcriptionally driven alterations in metabolism during compensatory growth, such as altered glycolysis and lipid metabolism activities. The metabolome data also implied the participation of amino acid metabolism during compensatory growth in zebrafish liver.ConclusionOur study provides a global resource for metabolic adaptations and their transcriptional regulation during refeeding in zebrafish liver. This study represents a first step towards understanding of the impact of metabolism on compensatory growth and will potentially aid in understanding the molecular mechanism associated with compensatory growth.
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