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Four New Picrotoxane-Type Sesquiterpenes From Dendrobium nobile Lindl

文献类型： 外文期刊

作者： Wang, Pei 1 ; Chen, Xin 1 ; Wang, Hao 1 ; Huang, Shengzhuo 1 ; Cai, Caihong 1 ; Yuan, Jingzhe 1 ; Zhu, Guoliang 3 ; Xu, X 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Key Lab Res & Dev Nat Prod Li Folk Med, Haikou, Hainan, Peoples R China

2.Nanjing Agr Univ, Nanjing, Jiangsu, Peoples R China

3.East China Univ Sci & Technol, Shanghai, Peoples R China

关键词： Dendrobium nobile Lindl; picrotoxane; sesquiterpenes; alpha-glycosidase inhibitor; cytotoxicity

期刊名称：FRONTIERS IN CHEMISTRY （ 影响因子：5.221； 五年影响因子：5.385 ）

ISSN： 2296-2646

年卷期： 2019 年 7 卷

页码：

收录情况： SCI

摘要： Four picrotoxane-type sesquiterpenes, dendroterpene A-D (1-4), together with four known compounds (5-8), were isolated from the stems of Dendrobium nobile Lindl. Their structures were elucidated by spectroscopic analysis, X-ray diffraction analysis, analysis of the ECD data according to the Klyne's lactone sector rule, and quantum ECD calculation. Compounds 1 and 2 are two new picrotoxane-type sesquiterpenes with a new carbon skeleton containing a formamide group, which may be derived from the previously reported dendrobiumane B skeleton by the C(9)-C(11) carbon bond cleavage. Compounds 3, 5, 6, and 8 exhibited inhibitory activity against alpha-glycosidase. Compounds 5 and 6 were cytotoxic against SGC-7901, K562, A549, BEL-7402, and Hela cell lines.

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