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Identification of targets and comparative study of administration methods for the lipid-lowering effects of fucoidan from Saccharina japonica

文献类型： 外文期刊

作者： Chen, Pengwei 1 ; Hao, Li 2 ; Li, Quancai 3 ; Wang, Hao 1 ; Chen, Huiqin 1 ; Zhang, Miao 4 ; Jia, Ang 5 ; Jiang, Hongfei 4 ; Dai, Haofu 1 ; Zhang, Renshuai 4 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Key Lab Res & Dev Nat Prod Li Folk Med, Haikou 571101, Peoples R China

2.Shandong First Med Univ & Shandong Prov Qianfoshan, Affiliated Hosp 1, Dept Gerontol, Jinan 528051, Peoples R China

3.Ocean Univ China, Marine Biomed Res Inst Qingdao, Qingdao 266003, Peoples R China

4.Qingdao Univ, Affiliated Hosp, Qingdao 266071, Peoples R China

5.Jinzhou Med Univ, Affiliated Hosp 1, Jinzhou 121000, Peoples R China

关键词： Fucoidan; Lipid-lowering activity; Dietary supplementation; Intestinal target; Gut microbiota

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.5； 五年影响因子：8.7 ）

ISSN： 0141-8130

年卷期： 2025 年 290 卷

页码：

收录情况： SCI

摘要： The lipid-lowering activity of fucoidan has been widely reported, but the exploration of its mechanisms is relatively limited, and studies on its direct targets are even scarcer. Additionally, it is unclear whether different administration methods affect the lipid-lowering activity of fucoidan. In current study, we used fucoidan derived from Saccharina japonica (SJF) to investigate its targets. The results showed that not only did SJF directly inhibit the Niemann-Pick C1-like 1 (NPC1L1)-mediated cholesterol transport, but it also reduced the solubility of cholesterol in mixed micelles, thereby interfering with the cholesterol uptake. Furthermore, SJF not only directly inhibited the activity of pancreatic triglyceride lipase (PTL), but also interfered with the overall catalytic process facilitated by colipase, thereby reducing the absorption of triglycerides. Moreover, comparative studies on the lipid-lowering activity of SJF administered via different methods demonstrated that dietary supplementation with SJF provided better lipid-lowering effects compared with gavage administration. Our research not only elucidates the targets and mechanisms of SJF but also provides theoretical basis for the selection of administration methods for fucoidan in lipid-lowering therapy.

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