文献类型： 外文期刊
作者： Wen, Wen 1 ; Yang, Delan 1 ; Wang, Hao 2 ; Chen, Huiqin 2 ; Zeng, Yanbo 2 ;
作者机构： 1.Chongqing Univ Technol, Sch Pharm & Bioengn, Chongqing 400054, Peoples R China
2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Prov Key Lab Funct Components Res & Utiliza, Haikou 571101, Peoples R China
关键词： Soft coral; Cladiella sp.; Steroid; Anti-inflammatory
期刊名称：PHYTOCHEMISTRY LETTERS （ 影响因子：1.4； 五年影响因子：1.5 ）
ISSN： 1874-3900
年卷期： 2025 年 66 卷
页码：
收录情况： SCI
摘要： A new undescribed steroid 23,24-epoxy-24-methylchol-5-ene-3/3-ol (1), together with two known steroids (24S)- 24-methylcholest-5-ene-3/3,25-diol (2) and 16-hydroxysarcosterol (3) was extracted from the soft coral Cladiella sp. Their structures were investigated by IR, MS, 1D and 2D NMR spectra, while QM-NMR calculations were utilized to ascertain the configuration of compound 1. The potential anti-inflammatory properties of all compounds were assessed. Compound 1 exerted a moderate suppressive effect on LPS-stimulated inflammatory reactions in RAW264.7 macrophage cells, with IC50 value of 32.93 +/- 2.32 mu M. Compounds 2 and 3 demonstrated weaker inhibitory effects, with IC50 values of 80.05 +/- 7.11 and 54.05 +/- 2.82 mu M, respectively.
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