Two unprecedented 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones with anti-Helicobacter pylori activity from agarwood of Aquilaria sinensis 'Reke 1'
文献类型： 外文期刊
作者： Qin, Ke-Xin 1 ; Wang, Hao 2 ; Yang, Li 2 ; Wei, Yan-Mei 2 ; Cai, Cai-Hong 2 ; Chen, Hui-Qin 2 ; Dong, Wen-Hua 2 ; Li, Wei 2 ; Yan, Xian-Yun 2 ; Zeng, Jun 2 ; Mei, Wen-Li 2 ; Jian, Jie 1 ; Dai, Haofu 2 ;
作者机构： 1.Guilin Med Univ, Coll Pharm, Guilin 541004, Peoples R China
2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Int Joint Res Ctr Agarwood, Hainan Engn Res Ctr Agarwood, Haikou 571101, Peoples R China
3.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Res & Dev Nat Prod Li Folk Med Hainan Prov, Haikou 571101, Peoples R China
关键词： Agarwood; Aquilaria sinensis 'Reke 1 '; 2-(2-Phenylethyl)chromone; Anti -Helicobacter pylori activity
期刊名称：PHYTOCHEMISTRY LETTERS （ 影响因子：1.4； 五年影响因子：1.5 ）
ISSN： 1874-3900
年卷期： 2025 年 66 卷
页码：
收录情况： SCI
摘要： Two new 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones (1 and 2), together with one known compound (3), were isolated from the ethanol extract of agarwood produced from Aquilaria sinensis 'Reke 1'. The structures of compounds 1 and 2 were precisely elucidated on the basis of HR-ESI-MS, 1D and 2D NMR, TDDFT-ECD, as well as by comparison with the literature data. All compounds were evaluated for anti-Helicobacter pylori activity. Compound 2 exhibited significant inhibitory effect against H. pylori with the minimum inhibition concentration (MIC) value of 20 mu M.
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