文献类型： 外文期刊
作者： Zhang, Tingting 1 ; Yuan, Dongwei 1 ; Xie, Jun 5 ; Lei, Yongxing 4 ; Li, Jianguo 7 ; Fang, Gangqi 3 ; Tian, Ling 8 ; Liu, 1 ;
作者机构： 1.South China Normal Univ, Inst Insect Sci & Technol, Sch Life Sci, Guangdong Prov Key Lab Insect Dev Biol & Appl Tec, Guangzhou, Guangdong, Peoples R China
2.Shanxi Univ, Res Inst Appl Biol, Taiyuan, Shanxi, Peoples R China
3.Chinese Acad Sci, CAS Ctr Excellence Mol Plant Sci, CAS Key Lab Insect Dev & Evolutionary Biol, Inst Plant Physiol & Ecol, Shanghai, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
5.Fudan Univ, Inst Genet, Sch Life Sci, State Key Lab Genet Engn, Shanghai, Peoples R China
6.Chinese Acad Sci, Inst Plant Physiol & Ecol, Key Lab Synthet Biol, Shanghai, Peoples R China
7.Shanxi Univ, Inst Biomed Sci, Taiyuan, Shanxi, Peoples R China
8.South China Agr Univ, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Guangdong Prov Sericulture & Mulberry Engn Res Ct, Coll Anim Sci, Guangzhou, Guangdong, Peoples R China
9.Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Innovat Ctr Cell Signaling Network, State Key Lab Mol Biol,CAS Ctr Excellence Mol Cel, Shanghai, Peoples R China
10.Chinese Acad Sci, Nanjing Inst Geol & Palaeontol, State Key Lab Paleobiol & Stratig, Nanjing, Jiangsu, Peoples R China
关键词： cholesterol biosynthesis pathway; gene loss; Ediacaran period; macroevolution
期刊名称：MOLECULAR BIOLOGY AND EVOLUTION （ 影响因子：16.24； 五年影响因子：18.67 ）
ISSN： 0737-4038
年卷期： 2019 年 36 卷 11 期
页码：
收录情况： SCI
摘要： Cholesterol plays essential roles in animal development and disease progression. Here, we characterize the evolutionary pattern of the canonical cholesterol biosynthesis pathway (CBP) in the animal kingdom using both genome-wide analyses and functional experiments. CBP genes in the basal metazoans were inherited from their last common eukaryotic ancestor and evolutionarily conserved for cholesterol biosynthesis. The genomes of both the basal metazoans and deuterostomes retain almost the full set of CBP genes, while Cnidaria and many protostomes have independently experienced multiple massive losses of CBP genes that might be due to the geologic events during the Ediacaran period, such as the appearance of an exogenous sterol supply and the frequent perturbation of ocean oxygenation. Meanwhile, the indispensable utilization processes of cholesterol potentially strengthened the maintenance of the complete set of CBP genes in vertebrates. These results strengthen both biotic and abiotic roles in the macroevolution of a biosynthesis pathway in animals.
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