文献类型： 外文期刊
作者： Xiao, Ying 1 ; Xu, Bing 1 ; Kang, You 2 ; Li, Yuedi 1 ; Cui, Yong 3 ; Liu, Wei 4 ; Xiang, Zheng 4 ;
作者机构： 1.Shenyang Brain Hosp, Shenyang Peoples Hosp 1, Shenyang Brain Inst, Dept Neurol & Neurosci, Shenyang, Peoples R China
2.Jilin Acad Agr Sci, Jilin, Jilin, Peoples R China
3.Shenyang Pharmaceut Univ, Sch Med Devices, Shenyang 110016, Peoples R China
4.Liaoning Univ, Sch Pharmaceut Sci, Shenyang 110036, Peoples R China
关键词： Soil fungus Hypoxylon sp.; metabolite; NMR spectrum; ECD; chemical constituent; anti-neuroinflammatory
期刊名称：LETTERS IN ORGANIC CHEMISTRY （ 影响因子：0.867； 五年影响因子：0.865 ）
ISSN： 1570-1786
年卷期： 2020 年 17 卷 2 期
页码：
收录情况： SCI
摘要： Hypoxylon sp. was used to ferment at 25 degrees C for 45 days. The solid culture of Hypoxylon sp. was extracted with 75% EtOH under ultrasonic for twice. And the dried combined extracts were then suspended in H2O and partitioned with ethyl acetate. EtOAc extracts were subjected to a silica gel column and eluted with petroleum ether - acetone to afford seven fractions. Sephadex LH-20 and RP-HPLC were used subsequently to yield a novel xanthone metabolite (Hypoxylon xanthone A). Its structure was elucidated based on HR-ESI-MS, 1D-, 2D-NMR spectra, and the comparison of the experimental and calculated ECU spectra. The anti-neuroinflammatory assay of Hypoxylon xanthone A, as manifested by the inhibitory effect on LPS-induced NO production in BV-2 microglial cells, indicated almost the same inhibitory effect as minocycline in a dose-dependent manner within the concentration of 1-50 mu M, suggesting that Hypoxylon xanthone A could be a new potential neuroinflammation inhibitor.
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