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Proliferation characteristics of the intracellular microsporidian pathogen Nosema bombycis in congenitally infected embryos

文献类型： 外文期刊

作者： Song, Yue 1 ; Tang, Yunlin 1 ; Yang, Qiong 5 ; Li, Tangxin 1 ; He, Zhangshuai 1 ; Wu, Yujiao 1 ; He, Qiang 1 ; Li, Tian 1 ;

作者机构： 1.Southwest Univ, State Key Lab Silkworm Genome Biol, Chongqing, Peoples R China

2.Southwest Univ, Chongqing Key Lab Microsporidia Infect & Control, Chongqing, Peoples R China

3.Chongqing Normal Univ, Coll Life Sci, Chongqing, Peoples R China

4.Southwest Univ, Coll Biotechnol, Key Lab Sericultural Biol & Genet Breeding, Minist Agr, Chongqing, Peoples R China

5.Guangdong Acad Agr Sci, Sericulture & Agrifood Res Inst, Guangzhou, Peoples R China

关键词： Microsporidia; Nosema bombycis; Embryo; Congenital infection; Vertical transmission

期刊名称：JOURNAL OF INVERTEBRATE PATHOLOGY （ 影响因子：2.841； 五年影响因子：3.368 ）

ISSN： 0022-2011

年卷期： 2020 年 169 卷

页码：

收录情况： SCI

摘要： Nosema bombycis is an obligate intracellular pathogen that can be transmitted vertically from infected females to eggs, resulting in congenital infections in embryos. Here we investigated the proliferation characteristics of N. bombycis in silkworm embryos using a histopathological approach and deep RNA sequencing. We found that N. bombycis proliferated mainly around yolk granules at the early stage of the embryonic development, 1-2 days post oviposition (dpo). At 4-6 dpo, a portion of N. bombycis in different stages adjacent to the embryo were packaged into the newly formed intestinal lumen, while the remaining parasites continued to proliferate around yolk granules. In the newly hatched larvae (9 dpo), the newly formed spores accumulated in the gut lumen and immediately were released into the environment via the faeces. Transcriptional profiling of N. bombycis further confirmed multiplication of N. bombycis throughout every stage of embryonic development. Additionally, the increased transcriptional level of spore wall proteins and polar tube proteins from 4 dpo indicated an active formation of mature spores. Taken together, our results have provided a characterization of the proliferation of this intracellular microsporidian pathogen in congenitally infected embryos leading to vertical transmission.

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