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Three new compounds from the litters of Casuarina equisetifolia

文献类型： 外文期刊

作者： Wang, Pei 1 ; Wang, Haisheng 1 ; Cai, Caihong 1 ; Wang, Hao 1 ; Kong, Fandong 1 ; Yuan, Jingzhe 1 ; Dai, Haofu 1 ; Li, Le 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Key Lab Res & Dev Nat Prod Li Folk Med, Haikou 571101, Hainan, Peoples R China

2.Hainan Normal Univ, Coll Life Sci, Haikou 570228, Hainan, Peoples R China

关键词： Casuarina equisetifolia; Litters; alpha-glycosidase inhibition activity; Acetyl cholinesterase (AChE) inhibition activity

期刊名称：PHYTOCHEMISTRY LETTERS （ 影响因子：1.679； 五年影响因子：1.861 ）

ISSN： 1874-3900

年卷期： 2020 年 35 卷

页码：

收录情况： SCI

摘要： Two new cyclic diarylheptanoids, casuaritriol A (1) and casuaritriol B (2), were isolated from the EtOAc extract of litters (including branches and leaves) of Casuarina equisetifolia, along with a new triterpene casuariene (3), and two known compounds diarylheptanoids adanin (4) and ostryopsitriol (5). Their structures were elucidated by spectroscopic analysis (including HRESIMS, 1D NMR and 2D NMR data), and the absolute configuration of 3 was determined by analysis of the ECD data according to the octant rule. Compound 1 exhibited inhibitory activity against alpha-glycosidase with inhibition rate of 45.1 +/- 1.4 % at a concentration of 500 mu g/mL. In addition, compound 4 showed weak inhibitory activity against acetyl cholinesterase (AChE) with inhibition rate of 14.9 +/- 1.1 % at a concentration of 50 mu g/mL.

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