Malic enzyme 1 is important for uterine decidualization in response to progesterone/cAMP/PKA/HB-EGF pathway
文献类型： 外文期刊
作者： Yu, Hai-Fan 1 ; Duan, Cui-Cui 2 ; Yang, Zhan-Qing 1 ; Wang, Yu-Si 1 ; Yue, Zhan-Peng 1 ; Guo, Bin 1 ;
作者机构： 1.Jilin Univ, Coll Vet Med, Changchun 130062, Peoples R China
2.Jilin Acad Agr Sci, Inst Agrofood Technol, Changchun, Peoples R China
关键词： decidualization; Me1; mitochondrial function; HB-EGF; progesterone-cAMP-PKA pathway; uterus
期刊名称：FASEB JOURNAL （ 影响因子：5.191； 五年影响因子：5.955 ）
ISSN： 0892-6638
年卷期： 2020 年 34 卷 3 期
页码：
收录情况： SCI
摘要： Malic enzyme 1 (Me1), a member of the malic enzymes involving in glycolytic pathway and citric acid cycle, is essential for the energy metabolism and maintenance of intracellular redox balance state, but its physiological role and regulatory mechanism in the uterine decidualization are still unknown. Current study showed that Me1 was strongly expressed in decidual cells, and could promote the proliferation and differentiation of stromal cells followed by an accelerated cell cycle transition, indicating an importance of Me1 in the uterine decidualization. Silencing of Me1 attenuated NADPH generation and reduced GR activity, while addition of NADPH improved the defect of GR activity elicited by Me1 depletion. Further analysis found that Me1 modulated intracellular GSH content via GR. Meanwhile, Me1 played a role in maintaining mitochondrial function as indicated by these observations that blockadge of Me1 led to the accumulation of mitochondrial O2- level and decreased ATP production and mtDNA copy numbers accompanied with defective mitochondrial membrane potential. In uterine stromal cells, progesterone induced Me1 expression through PR-cAMP-PKA pathway. Knockdown of HB-EGF might impede the regulation of progesterone and cAMP on Me1. Collectively, Me1 is essential for uterine decidualization in response to progesterone/cAMP/PKA/HB-EGF pathway and plays an important role in preventing mitochondrial dysfunction.
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