Glutamate and aspartate alleviate testicular/epididymal oxidative stress by supporting antioxidant enzymes and immune defense systems in boars
文献类型： 外文期刊
作者： Tang, Wenjie 1 ; Wu, Jian 2 ; Jin, Shunshun 2 ; He, Liuqin 1 ; Lin, Qinlu 3 ; Luo, Feijun 3 ; He, Xingguo 6 ; Feng, Yanzh 1 ;
作者机构： 1.Hunan Normal Univ, Coll Life Sci, Lab Anim Nutr & Human Hlth, Hunan Int Joint Lab Anim Intestinal Ecol & Hlth, Changsha 410081, Peoples R China
2.Chinese Acad Sci, Hunan Prov Key Lab Anim Nutrit Physiol & Metab Pr, Natl Engn Lab Pollut Control & Waste Utilizat Liv, Key Lab Agroecol Proc Subtrop Reg, Changsha 410125, Peoples R China
3.Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Hunan Key Lab Proc Food Special Med Purpose, Natl Engn Lab Deep Proc Rice & Byprod,Hunan Key L, Changsha 410004, Peoples R China
4.Changsha Med Univ, Affiliated Hosp 1, Acad Working Stn, Changsha 410219, Peoples R China
5.Sichuan Acad Anim Sci, Anim Breeding & Genet Key Lab Sichuan Prov, Chengdu 610066, Peoples R China
6.Changsha Green Leaf Biotechnol Co Ltd, Changsha 610066, Hunan, Peoples R China
7.Heilongjiang Acad Agr Sci, Harbin 150086, Peoples R China
关键词： glutamate; aspartate; boars; oxidative stress; inflammatory cytokines
期刊名称：SCIENCE CHINA-LIFE SCIENCES （ 影响因子：6.038； 五年影响因子：4.754 ）
ISSN： 1674-7305
年卷期： 2020 年 63 卷 1 期
页码：
收录情况： SCI
摘要： Several potential oxidative agents have damaging effects on mammalian reproductive systems. This study was conducted to investigate the effects of glutamate (Glu) and aspartate (Asp) supplementation on antioxidant enzymes and immune defense systems in the outer scrotum of boars injected with H2O2. A total of 24 healthy boars were randomly divided into 4 treatment groups: control (basal diet, saline-treated), H2O2 (basal diet, H2O2-challenged outer scrotum (1 mL kg(-1) BW)), Glu (basal diet +2% Glu, H2O2-challenged), and Asp (basal diet+2% Asp, H2O2-challenged). Our results showed that both Glu and Asp supplementation improved testicular morphology and decreased the genital index in the H2O2-treated boars. Glu and Asp administration increased the antioxidant enzyme activities and affected the testicular inflammatory cytokine secretion but had no effect on sex hormone levels. Furthermore, the mRNA expression of CAT, CuZnSOD, and GPx4 was altered in the testes and epididymis of boars treated with Asp and Glu. Glu and Asp supplementation also modulated the expression of TGF-beta 1, IL-10, TNF-alpha, IL-6 and IL-1 beta in the testis and epididymis. These results indicate that dietary Glu and Asp supplementation might enhance antioxidant capacity and regulate the secretion and expression of inflammatory cytokines to protect the testes and epididymis of boars against oxidative stress.
- 相关文献
作者其他论文 更多>>
-
Low-Temperature Fermented Straw Compost Regulates Rice Growth and Yield by Affecting Soil Physicochemical Properties and the Expression of Important Signaling Pathway Genes
作者：Liu, Tongtong;Zhao, Ziyi;Xu, Kai;Zhang, Nan;Wu, Juan;Liu, Ziguang;Chen, Heshu;Feng, Yanzhong;Wang, Wentao;Liu, Di;He, Xinmiao;Zhang, Nan
关键词：straw compost; rice; soil physicochemical properties; soil microbial diversity; transcriptome sequencing
-
Characterization of Growth Secondary Hair in Min Pig Activated by Follicle Stem Cell Stimulated by Wnt and BMP Signaling Pathway
作者：He, Xinmiao;Tian, Ming;Wang, Wentao;Feng, Yanzhong;Chen, Heshu;He, Haijuan;Zhang, Haifeng;Liu, Di;Qin, Ziliang;Teng, Ran;Liu, Di;Jiang, Xinpeng
关键词：Min pig; follicle stem cell; BMP; Wnt
-
Crosstalk between trace elements and T-cell immunity during early-life health in pigs
作者：He, Liuqin;Li, Jianzhong;Jin, Shunshun;Yang, Chenbo;He, Liuqin;Li, Tiejun;He, Xinmiao;Chen, Heshu;Feng, Yanzhong;Liu, Di;Tang, Wenjie
关键词：trace elements; T cells; pig; gut; immunity
-
Identification of Candidate Genes for Min Pig Villi Hair Traits by Genome-Wide Association of Copy Number Variation
作者：He, Xinmiao;Tian, Ming;Wang, Wentao;Feng, Yanzhong;Li, Zhongqiu;Liu, Di;Wang, Jiahui;Song, Yan;Zhang, Jinfeng
关键词：Min pig; villi hair follicle; copy number variation; genome-wide association study
-
Ferroptosis and Its Multifaceted Role in Cancer: Mechanisms and Therapeutic Approach
作者：Chen, Heshu;Wang, Chenyu;Liu, Zemin;He, Liuqin;Yin, Yulong;Li, Tiejun;Chen, Heshu;He, Xinmiao;Feng, Yanzhong;Liu, Di;Wang, Chenyu;He, Liuqin;Tang, Wenjie
关键词：ferroptosis; lipid peroxidation; iron; cancer; oxidative stress
-
Mycotoxins in livestock feed in China - Current status and future challenges
作者：Tian, Ming;Feng, Yanzhong;He, Xinmiao;Zhang, Dongjie;Wang, Wentao;Liu, Di;Tian, Ming;Feng, Yanzhong;He, Xinmiao;Zhang, Dongjie;Wang, Wentao;Liu, Di
关键词：Mycotoxin; Feed; Livestock; China; Animal health
-
Transcriptome Analysis Reveals Genes Contributed to Min Pig Villi Hair Follicle in Different Seasons
作者：Tian, Ming;He, Xinmiao;Wang, Wentao;Feng, Yanzhong;Zhang, Dongjie;Li, Zhongqiu;Liu, Di
关键词：Min pig; villi hair follicle; season
