文献类型： 外文期刊
作者： Chen, Heshu 1 ; Wang, Chenyu 1 ; Liu, Zemin 1 ; He, Xinmiao 2 ; Tang, Wenjie 4 ; He, Liuqin 1 ; Feng, Yanzhong 2 ; Liu, Di 2 ; Yin, Yulong 1 ; Li, Tiejun 1 ;
作者机构： 1.Chinese Acad Sci, Inst Subtrop Agr, Hunan Prov Key Lab Anim Nutr Physiol & Metab Proc, CAS Key Lab Agroecol Proc Subtrop Reg,Natl Engn L, Changsha 410125, Peoples R China
2.Heilongjiang Acad Agr Sci, Inst Anim Husb, Harbin 150086, Peoples R China
3.Hunan Normal Univ, Coll Life Sci, Hunan Prov Key Lab Anim Intestinal Funct & Regula, Lab Anim Nutr & Human Hlth, Changsha 410081, Peoples R China
4.Sichuan Anim Sci Acad, Anim Breeding & Genet Key Lab Sichuan Prov, Chengdu 610066, Peoples R China
关键词： ferroptosis; lipid peroxidation; iron; cancer; oxidative stress
期刊名称：ANTIOXIDANTS （ 影响因子：7.675； 五年影响因子：7.886 ）
ISSN：
年卷期： 2022 年 11 卷 8 期
页码：
收录情况： SCI
摘要： Ferroptosis, a new type of non-apoptotic cell death modality, is different from other modes of cell death and has been primarily found in tumor cells. Previous studies have reported that ferroptosis can be triggered by specific modulators (e.g., drugs, nutrients, and iron chelators), leading to increased intracellular lipid reactive oxygen species (ROS) accumulation and iron overload. Recent reports have shown that ferroptosis at the cellular and organism levels can prevent an inflammatory storm and cancer development. Emerging evidence suggests potential mechanisms (e.g., system Xc-, glutathione peroxidase 4 (GPX4), lipid peroxidation, glutathione (GSH), and iron chelators) are involved in ferroptosis, which may mediate biological processes such as oxidative stress and iron overload to treat cancer. To date, there are at least three pathways that mediate ferroptosis in cancer cells: system Xc-/GSH/GPX4, FSP1/CoQ10/NAD(P)H, and ATG5/ATG7/NCOA4. Here, we summarize recent advances in the occurrence and development of ferroptosis in the context of cancer, the associations between ferroptosis and various modulators, and the potential mechanisms and therapeutic strategies targeting ferroptosis for the treatment of cancer.
- 相关文献
作者其他论文 更多>>
-
The Role of β3-Adrenergic Receptors in Cold-Induced Beige Adipocyte Production in Pigs
作者：Yang, Shuo;Yang, Xiuqin;Ma, Hong;Wang, Liang;Wang, Fang;Liu, Di;Xia, Jiqiao;Liu, Dongyu;Mu, Linlin
关键词：cold stress; piglets; ADRB3; beige adipocytes; thermogenesis
-
Network Meta-Analysis: Effect of Cold Stress on the Gene Expression of Swine Adipocytes ATGL, CIDEA, UCP2, and UCP3
作者：Guo, Zhenhua;Liu, Di;Ma, Hong;Wang, Liang;Fu, Bo;Wang, Fang;Lv, Lei
关键词：beige adipose tissue; fat; pig; UCP1
-
TAP2 Effect on Min-Pig Stromal Vascular Fraction Cell Gene Expression
作者：Wang, Liang;Liu, Di;Ma, Hong;Zhang, Dongjie;He, Xinmiao;Wang, Wentao;Fu, Bo;Li, Zhongqiu;Guo, Zhenhua
关键词：gene interference; gene overexpression; Min-pig; SVF cells; TAP2
-
Essential roles of the nucleolus during early embryonic development: a regulatory hub for chromatin organization
作者：Fu, Bo;Ma, Hong;Liu, Di;Fu, Bo;Ma, Hong;Liu, Di
关键词：preimplantation embryo; nucleolus precursor bodies; chromatin organization; Dux; totipotency; somatic cell nuclear transfer
-
Insights into the transcriptomic mechanism and characterization of endoglucanases from Aspergillus terreus in cellulose degradation
作者：Liu, Xin;Wang, Yanbo;Zhang, Rui;Hu, Xiaomei;Gao, Yunfei;Chen, Heshu;Dong, Shijia
关键词：Lignocellulose; Transcriptome; Endoglucanases; Molecular docking
-
Inoculating functional bacteria improved the humification process by regulating microbial networks and key genera in straw composting by adding different nitrogen sources
作者：Dong, Shijia;Wei, Yiyang;Yu, Qi;Hu, Xiaomei;Gao, Yunfei;Chen, Heshu;Zhou, Kaiyun;Wei, Yuquan;Cheng, Meidi;Wang, Bo
关键词：Agricultural waste composting; Bioaugmentation; Humus; Lignocellulose degradation; Nitrogen sources addition
-
Pioneer Transcription Factors: The First Domino in Zygotic Genome Activation
作者：Fu, Bo;Ma, Hong;Liu, Di;Fu, Bo;Ma, Hong;Liu, Di
关键词：pioneer transcription factors; preimplantation embryo; zygotic genome activation; retrotransposons
