Duckling short beak and dwarfism syndrome virus infection activates host innate immune response involving both DNA and RNA sensors
文献类型： 外文期刊
作者： Chen, Shilong 1 ; Fang, Tiehui 4 ; Xiao, Shifeng 1 ; Lin, Fengqiang 1 ; Cheng, Xiaoxia 1 ; Wang, Shao 1 ; Zhu, Xiaoli; 1 ;
作者机构： 1.Fujian Acad Agr Sci, Inst Anim Husb & Vet Med, Fuzhou 350013, Peoples R China
2.Longyan Univ, Longyan 364012, Peoples R China
3.Fujian Prov Key Lab Prevent & Control Anim Infect, Longyan 364012, Peoples R China
4.Fujian Agr & Forestry Univ, Coll Anim Sci, Fuzhou 350002, Peoples R China
5.Univ Lancaster, Fac Hlth & Med, Div Biomed & Life Sci, Lancaster, England
6.Fujian Acad Agr Sci, Inst Biotechnol, Fuzhou 350003, Peoples R China
关键词： Duckling short beak and dwarfism syndrome virus (SBDSV); Goose parvovirus; Duck embryo fibroblast; Innate immune response; Pattern recognition receptors
期刊名称：MICROBIAL PATHOGENESIS （ 影响因子：3.738； 五年影响因子：3.663 ）
ISSN： 0882-4010
年卷期： 2020 年 138 卷
页码：
收录情况： SCI
摘要： Duckling short beak and dwarfism syndrome virus (SBDSV), a newly identified goose parvovirus, causes devastating disease in domestic waterfowl and considerable economic losses to Chinese waterfowl industry. The molecular pathogenesis of SBDSV infection, nature and dynamics of host immune responses against SBDSV infection remained elusive. In this study, we systematically explored the relative mRNA expression profiles of major innate immune-related genes in SBDSV infected duck embryo fibroblasts. We found that SBDSV infection effectively activated host innate immune responses and resulted in significant up-regulation of IFN-beta and several vital IFN-stimulated genes (ISGs). These up-regulation responses were mainly attributed to viral genomic DNA and dsRNA replication intermediates. Importantly, the expression of cGAS was significantly induced, whereas the expression of other DNA receptors including DDX41, STING, ZBP1, LSM14A and LRRFIP1 have no significant change. Furthermore, SBDSV infection also activates the up-regulation of TLR3 and inhibited the expression of TLR2 and TLR4; however, no effect was observed on the expression of TLR1, TLR5, TLR7, TLR15 and TLR21. Intriguingly, SBDSV infection significantly up-regulated the expression of RNA sensors such as MDA5 and LGP2, and resulted in a delayed but significant up-regulation of RIG-I gene. Taken together, these data indicate that host multiple sensors including DNA sensor (cGAS) and RNA sensors (TLR3, MDA5 and LGP2) are involved in recognizing a variety of different pathogen associated molecular patterns (PAMPs) including viral genomic ssDNA and dsRNA replication intermediates, which trigger an effective antiviral innate immune response.
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