Benzo-pyrrolidinyl substituted silicon phthalocyanines: A novel two-photon lysosomal nanoprobe for in vitro photodynamic therapy
文献类型： 外文期刊
作者： Chen, Xiuqin 1 ; Chen, Guizhi 1 ; Cao, Sitong 1 ; Ye, Ruoxin 1 ; Qiu, Ruoyi 1 ; Yang, Xiangyu 1 ; Peng, Yiru 1 ; Sun, Hong 3 ;
作者机构： 1.Fujian Normal Univ, Coll Chem & Mat, Fujian Prov Key Lab Polymer Mat, Fujian Prov Key Lab Adv Mat Oriented Chem Engn, Fuzhou, Peoples R China
2.Fujian Acad Agr Sci, Inst Plant Protect, Fuzhou, Peoples R China
3.Fujian Med Univ, Fuzhou Univ Affiliated Prov Hosp, Fujian Prov Hosp, Shengli Clin Med Coll,Dept Pharm, Fuzhou 350001, Peoples R China
关键词： Pyrrolidine ketone; Phthalocyanine; Lysosomal targeting; Two-photon fluorescence imaging; Photodynamic therapy
期刊名称：PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY （ 影响因子：2.6； 五年影响因子：3.1 ）
ISSN： 1572-1000
年卷期： 2025 年 51 卷
页码：
收录情况： SCI
摘要： Lysosomes are pivotal in diverse physiological phenomena, encompassing autophagy, apoptosis, and cellular senescence. The demand for precise tumors treatment has led to the development of specific lysosome-targeting probes capable of elucidating lysosomal dynamics and facilitating targeted cell death. In this research, we report the synthesis and characterization of a novel benzopyrrolidinyl-substituted silicon phthalocyanine (Py-SiPc), designed for selective lysosome labeling and Fluorescence imaging-guided in vitro photodynamic therapy. Furthermore, we encapsulated Py-SiPc within a biocompatible nanocarrier, dipalmitoylphosphatidylethanolaminepolyethylene glycol 2000 (DSPE), to create water-soluble nanoparticles (DSPE@Py-SiPc). These nanoparticles exhibit exceptional lysosome labeling capabilities, as evidenced by bioimaging techniques. Upon exposure to laser irradiation, DSPE@Py-SiPc efficiently induces the production of reactive oxygen species, impairing lysosomal function and triggering lysosomal-mediated cell death. The DSPE@Py-SiPc system emerges as a promising photosensitizer.
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