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Comparison of Anthraquinones, Iridoid Glycosides and Triterpenoids in Morinda officinalis and Morinda citrifolia Using UPLC/Q-TOF-MS and Multivariate Statistical Analysis

文献类型： 外文期刊

作者： Wang, Maoyuan 1 ; Wang, Qinglong 1 ; Yang, Qing 1 ; Yan, Xiaoxia 1 ; Feng, Shixiu 3 ; Wang, Zhunian 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Trop Crops Genet Resources Inst, Minist Agr, Key Lab Crop Gene Resources & Germplasm Enhanceme, Haikou 571101, Hainan, Peoples R China

2.Minist Agr, Trop Wild Plant Gene Resource, Danzhou 571737, Peoples R China

3.Shenzhen & Chinese Acad Sci, Key Lab South Subtrop Plant Divers, Fairy Lake Bot Garden, Shenzhen 518004, Peoples R China

关键词： Morinda officinalis; Morinda citrifolia; UPLC/Q-TOF-MS; multivariate statistical analysis

期刊名称：MOLECULES （ 影响因子：4.411； 五年影响因子：4.587 ）

ISSN：

年卷期： 2020 年 25 卷 1 期

页码：

收录情况： SCI

摘要： Roots of Morinda officinalis and Morinda citrifolia have been interchangeably used in traditional Chinese medicine. However, there is no experimental evidence to support this. In this study, a ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF-MS)-based approach and a multivariate statistical analysis (MSA) were adopted to compare the difference in the chemical compounds present in the root extract of M. officinalis and M. citrifolia. There were 26 anthraquinones, 15 triterpenes, and 8 iridoid glycosides identified in the root extracts of M. officinalis, 30 anthraquinones, 1 triterpene, and 8 iridoid glycosides in the root extracts of M. citrifolia. Among these, 25 compounds presented in both plants. In addition, a principal component analysis (PCA) showed that these two herbs could be separated clearly. Furthermore, an orthogonal partial least squares-discriminant analysis (OPLS-DA) found 9 components that could be used as chemical markers to discrimination the root extracts of M. officinalis and M. citrifolia. In addition, the results of a Cell Counting Kit 8 (CCK-8) assay and cell colony formation assay indicated that methanol root extracts of M. officinalis and M. citrifolia showed no cell cytotoxicity to normal cells, even promoted the proliferation of normal liver cells. To our knowledge, this is the first time that the differences between the root extracts of M. officinalis and M. citrifolia (Hainan province) have been observed systematically at the chemistry level.

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