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Exploring the correlation between deltamethrin stress and Keap1-Nrf2-ARE pathway from Drosophila melanogaster RNASeq data

文献类型： 外文期刊

作者： Liu, Yahui 1 ; Ge, Mengying 1 ; Zhang, Tingting 1 ; Chen, Lu 1 ; Xing, Yuping 1 ; Liu, Liu 1 ; Li, Fengliang 2 ; Cheng, L 1 ;

作者机构： 1.Nanjing Normal Univ, Coll Life Sci, Jiangsu Key Lab Biodivers & Biotechnol, Nanjing 210023, Peoples R China

2.Guizhou Acad Agr Sci, Inst Plant Protect, Guiyang 550009, Peoples R China

关键词： Deltamethrin; Keap1-Nrf2-ARE pathway; Drosophila Kc cells; RNA-Seq; Detoxification

期刊名称：GENOMICS （ 影响因子：5.736； 五年影响因子：4.939 ）

ISSN： 0888-7543

年卷期： 2020 年 112 卷 2 期

页码：

收录情况： SCI

摘要： Deltamethrin (DM) is widely used in a variety of pest control, resulting in serious drug resistance. Keap1-Nrf2-ARE is the antioxidant stress pathway. We identified 268 genes differentially expressed (DEGs) in Drosophila Kc cells treated with DM, including up-regulated 180 genes and down-regulated 88 genes compared with the control group (fold-change >= 2, qValue <= 0.001) by RNA-seq, they are mainly linked to metabolic process, stimulation response, immune system process. When the cells are treated with DM in the case of overexpression of the Keap1 gene, the cytochrome P450 family genes were significantly down-regulated, and some diseases-related genes and non-coding genes also changed. Our data shown that Keap1-Nrf2-ARE pathway may play an important role in DM stress, which will provide a new direction for studying the mechanism of insect resistance.

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